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Rabbit Anti-TSLP/PE-Cy5.5 Conjugated antibody (bs-0449R-PE-Cy5.5)
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說(shuō) 明 書: 100ul  
100ul/2980.00元
大包裝/詢價(jià)
產(chǎn)品編號(hào) bs-0449R-PE-Cy5.5
英文名稱1 Rabbit Anti-TSLP/PE-Cy5.5 Conjugated antibody
中文名稱 PE-Cy5.5標(biāo)記的胸腺基質(zhì)淋巴細(xì)胞生成素-1抗體
別    名 Thymic stromal lymphopoietin isoform 1; Thymic stromal lymphopoietin; Thymic stromal lymphopoietin protein TSLP; TSLP protein; TSLP_HUMAN.  
規(guī)格價(jià)格 100ul/2980元 購(gòu)買        大包裝/詢價(jià)
說(shuō) 明 書 100ul  
研究領(lǐng)域 細(xì)胞生物  免疫學(xué)  細(xì)胞因子  
抗體來(lái)源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) (predicted: Human, )
產(chǎn)品應(yīng)用 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 15kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human TSP-1
亞    型 IgG
純化方法 affinity purified by Protein A
儲(chǔ) 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
Thymic stromal lymphopoietin (TSLP) is a novel cytokine that was found to promote the development of murine B cells in vitro. This protein, which is expressed in a number of tissues including heart, liver and prostate, prevented apoptosis and stimulated growth of the human acute myeloid leukemia (AML)-derived cell line MUTZ-3. Anti-interleukin (IL)-7 receptor antibodies (Abs) neutralized this effect indicating that TSLP binds to at least part of the IL-7 receptor complex. TSLP induced phosphorylation of signal transducer and activator of transcription (STAT)-5.

Function:
Cytokine that induces the release of T-cell-attracting chemokines from monocytes and, in particular, enhances the maturation of CD11c(+) dendritic cells. Can induce allergic inflammation by directly activating mast cells.

Subunit:
Interacts with a receptor composed of CRLF2 and IL7R.

Subcellular Location:
Secreted.

Tissue Specificity:
Expressed in a number of tissues including heart, liver and prostate.

Database links:

Entrez Gene: 85480 Human

Entrez Gene: 53603 Mouse

Entrez Gene: 688621 Rat

Omim: 607003 Human

SwissProt: Q969D9 Human

SwissProt: Q9JIE6 Mouse

Unigene: 389874 Human

Unigene: 143716 Mouse

Unigene: 201724 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

胸腺基質(zhì)淋巴細(xì)胞生成素-1(胸腺基質(zhì)細(xì)胞分泌的淋巴細(xì)胞生成素-1)
為一種新型促進(jìn)生長(zhǎng)的細(xì)胞因子——胸腺基質(zhì)淋巴蛋白(TSLP)可以引發(fā)炎癥反應(yīng), 這種炎癥反應(yīng)可以引起很多過(guò)敏性疾病和哮喘。
TSLP可能是過(guò)敏性疾病最重要的引發(fā)劑,已得到科學(xué)家的重視,如果證實(shí)了 TSLP是一種起始因子,抑制TSLP可以有效地治療哮喘和其它過(guò)敏性疾病。
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