亚洲中文字幕特级毛片-亚洲制服丝袜中文字幕-亚洲制服丝袜在线观看-亚洲制服欧美自拍另类-免费一级黄色-免费一级国产生活片

掃碼關(guān)注公眾號           掃碼咨詢技術(shù)支持           掃碼咨詢技術(shù)服務(wù)
  
客服熱線:400-901-9800  客服QQ:4009019800  技術(shù)答疑  技術(shù)支持  質(zhì)量反饋  關(guān)于我們  聯(lián)系我們
国产精品精品自在线拍,欧美巨大xxxx做受中文字幕,中文字幕人成无码免费视频
Rabbit Anti-MUC4/Biotin Conjugated antibody (bs-1994R-Bio)
訂購熱線:400-901-9800
訂購郵箱:sales@www.chomd.com.cn
訂購QQ:  400-901-9800
技術(shù)支持:techsupport@www.chomd.com.cn
說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產(chǎn)品編號 bs-1994R-Bio
英文名稱 Rabbit Anti-MUC4/Biotin Conjugated antibody
中文名稱 生物素標(biāo)記的粘蛋白4抗體
別    名 Mucin4; Mucin-4; Mucin 4; Muc4; MUC-4; Ascites sialoglycoprotein; ASGP; Pancreatic adenocarcinoma mucin; Testis mucin; Tracheobronchial mucin; Mucin-4 alpha chain; Ascites sialoglycoprotein 1; ASGP-1; Mucin-4 beta chain; Ascites sialoglycoprotein 2; ASGP-2; Mucin 4 cell surface associated; Mucin 4 tracheobronchial; Tracheobronchial mucin Fragment; MUC4_HUMAN.  
規(guī)格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
研究領(lǐng)域 腫瘤  微生物學(xué)  信號轉(zhuǎn)導(dǎo)  細胞骨架  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Human, Mouse,  (predicted: Rat, Pig, Cow, Horse, Guinea Pig, )
產(chǎn)品應(yīng)用 WB=1:50-200 ELISA=1:100-1000 IHC-P=1:50-200 IHC-F=1:50-200 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 80kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human Mucin-4 beta chain
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
The major constituents of mucus, the viscous secretion that covers epithelial surfaces such as those in the trachea, colon, and cervix, are highly glycosylated proteins called mucins. These glycoproteins play important roles in the protection of the epithelial cells and have been implicated in epithelial renewal and differentiation. This gene encodes an integral membrane glycoprotein found on the cell surface, although secreted isoforms may exist. At least two dozen transcript variants of this gene have been found, although for many of them the full-length transcript has not been determined or they are found only in tumor tissues. This gene contains a region in the coding sequence which has a variable number (>100) of 48 nt tandem repeats. [provided by RefSeq].

Function:
May play a role in tumor progression. Ability to promote tumor growth may be mainly due to repression of apoptosis as opposed to proliferation. Has anti-adhesive properties. Seems to alter cellular behavior through both anti-adhesive effects on cell-cell and cell-extracellular matrix interactions and in its ability to act as an intramembrane ligand for ERBB2. Plays an important role in cell proliferation and differentiation of epithelial cells by inducing specific phosphorylation of ERBB2. The MUC4-ERBB2 complex causes site-specific phosphorylation of the ERBB2 'Tyr-1248'. In polarized epithelilal cells segragates ERBB2 and other ERBB receptors and prevents ERBB2 from acting as a coreceptor. The interaction with ERBB2 leads to enhanced expression of CDKN1B. The formation of a MUC4-ERBB2-ERBB3-NRG1 complex leads to down-regulation of CDKN1B, resulting in repression of apoptosis and stimulation of proliferation.

Subunit:
A heterodimeric complex, composed of a mucin-4 alpha chain and a cysteine-rich transmembrane mucin-4 beta chain. Mucin-4 beta chain interacts with ERBB2 via the EGF-like domain 1. In nonpolarized cells, associates with ERBB2 and ERBB3.

Subcellular Location:
Membrane; Single-pass membrane protein (Potential). Secreted. Note=Isoforms lacking the Cys-rich region, EGF-like domains and transmembrane region are secreted. Secretion occurs by splicing or proteolytic processing.
Mucin-4 beta chain: Cell membrane; Single-pass membrane protein.
Mucin-4 alpha chain: Secreted.
Isoform 3, 17: Cell membrane; Single-pass membrane protein. Isoform 11, 15: Secreted.

Tissue Specificity:
Expressed in the thymus, thyroid, lung, trachea, esophagus, stomach, small intestine, colon, testis, prostate, ovary, uterus, placenta, and mammary and salivary glands. Expressed in carcinomas arising from some of these epithelia, such as lung cancers, squamous cell carcinomas of the upper aerodigestive tract, mammary carcinomas, biliary tract, colon, and cervix cancers. Minimally or not expressed in the normal pancreas or chronic pancreatitis, but is highly expressed in pancreatic tumors and pancreatic tumor cell lines.

Post-translational modifications:
Proteolytically cleaved into 2 chains, mucin-4 alpha chain and mucin-4 beta chain.
mucrnin-4 alpha chain is highly O-glycosylated.
mucin-4 beta chain is predominantly N-glycosylated.

Similarity:
Contains 1 AMOP domain.
Contains 2 EGF-like domains.
Contains 1 NIDO domain.
Contains 1 VWFD domain.

Database links:

Entrez Gene: 4585 Human

Entrez Gene: 140474 Mouse

Omim: 158372 Human

SwissProt: Q99102 Human

SwissProt: Q8JZM8 Mouse

Unigene: 369646 Human

Unigene: 214599 Mouse



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

腫瘤生物標(biāo)志Tumor biomarkers
版權(quán)所有 2004-2026 www.www.chomd.com.cn 北京博奧森生物技術(shù)有限公司
通過國際質(zhì)量管理體系ISO 9001:2015 GB/T 19001-2016    證書編號: 00124Q34771R2M/1100
通過國際醫(yī)療器械-質(zhì)量管理體系ISO 13485:2016 GB/T 42061-2022    證書編號: CQC24QY10047R0M/1100
京ICP備05066980號-1         京公網(wǎng)安備110107000727號
主站蜘蛛池模板: 麻豆久久久9性大片大香蕉| 国产亚洲精品无码AA在线观看| 里番无码在线侵犯| 91看片视频在线观看高清| 久久亚洲中文字幕无码一级特一区毛片 | 男人猛进猛出免费视频观看| 884aa四虎影成人精品一区潮喷 | 无码精品人妻一区二区三区ap小说 | 国产999精品久久久久久清| 日韩人妻中文在线视频免费视频| 91精品国产综合久久精品,亚洲精品国产专区9 | 岛国在线视频网站无码在线| 日本熟妇大BBB9| 又长又大又粗又硬3免费视频| 精品国产第一国产综合精品_a级毛片高 | 亚洲国产人久久综合区蜜| eeuss影院在线观看高清| 久久午夜夜伦鲁鲁片无码免费,久久人做人| 艳妇乳肉豪妇荡乳无码一区三区| 岛国无码一区二区三区毛片| 久久精品中文字幕一区二区三区公司| 亚洲国产久久久久久久久精品视频 | 激情亚洲欧洲小说图片在线观看 | 18护士一区二区三区免费 | 国产三级精品久久久剪级| 久热精品视频第一页免费观看| 亚洲熟妇av一区网址| 18禁网站免费无遮挡无码中文_日韩欧美中文 | 亚洲精品91在线VIP| 中文字幕日韩一区二区不卡,久青草国 | 精品无码国产污污污免费网站密桃| 小草青青电视剧全集免费观看 | 一级做a爰全过程免费视频,日韩一区二区三区四区区区 | 2022中文字幕在线观看视频a三区| 精品国产AV岛国涩涩一区精品| 区二区免费国产在线观看,一区二区| 亚洲精品无码成人片久久喷水入口 | 国产麻豆videoporono| 精品无码国产自产拍在线观看软件老太太拍拍拍 | 99精品久久99久久久久胖女人免费视频 | 久久96精品国产app|