| 產(chǎn)品編號 | bs-25230R |
| 英文名稱 | Rabbit Anti-EDA2R antibody |
| 中文名稱 | 腫瘤壞死因子受體超家族成員27抗體 |
| 別 名 | X linked ectodysplasin receptor; Ectodysplasin A2 isoform receptor; Ectodysplasin A2 receptor; EDA-A2 receptor; EDA2R; TNFRSF27; TNR27_HUMAN; Tumor necrosis factor receptor superfamily member 27; X linked ectodysplasin A2 receptor; X-linked ectodysplasin-A2 receptor; XEDAR. |
| 研究領(lǐng)域 | 細(xì)胞生物 信號轉(zhuǎn)導(dǎo) 干細(xì)胞 細(xì)胞凋亡 細(xì)胞周期蛋白 轉(zhuǎn)錄調(diào)節(jié)因子 |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | Human (predicted: Mouse,Rat) |
| 產(chǎn)品應(yīng)用 | WB=1:500-2000,ELISA=1:5000-10000
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理論分子量 | 33kDa |
| 細(xì)胞定位 | 細(xì)胞膜 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from mouse EDA2R: 1-100/297 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 緩 沖 液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事項(xiàng) | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 產(chǎn)品介紹 |
The tumor necrosis factor receptor (TNFR) superfamily represents a growing family of type I transmembrane glycoproteins that are involved in various cellular functions, including proliferation, differentiation and programmed cell death (1–3). These proteins share homology for cysteine-rich repeats in the extracellular ligand binding domain and an intracellular death domain (1–3). Members of the TNFR superfamily transmit signals through protein-protein interactions, and these signals can lead to the activation of either the caspase and Jun kinase pathways, which promote cell death, or the NFkB pathway, which results in cell survival (1). The ectodermal dysplasia receptor (EDAR) promotes all three of these pathways and mediates ectodermal differentiation (4). EDAR is encoded by the downless gene and is mutated in ectodermal dysplasia syndromes, which are characterized by impaired hair, teeth and sweat gland development (5). Ectodysplasin A (EDA) is a type II membrane protein that is encoded by the Tabby gene and produces many splice variants, the longest of which, EDA-A1, serves as the ligand for EDAR (5–7). EDA-A2, which differs from EDA-A1 by the deletion of two amino acids, binds only the X-linked ectodysplasin-A2 receptor (XEDAR) (7). Both EDAR and XEDAR exhibit homology with TROY (8). Function: Receptor for EDA isoform A2, but not for EDA isoform A1. Mediates the activation of the NF-kappa-B and JNK pathways. Activation seems to be mediated by binding to TRAF3 and TRAF6. Subunit: Associates with TRAF1, TRAF3 and TRAF6. Subcellular Location: Membrane; Single-pass type III membrane protein. Similarity: Contains 3 TNFR-Cys repeats. SWISS: Q8BX35 Gene ID: 245527 Database links: Entrez Gene: 60401 Human Entrez Gene: 245527 Mouse GenBank: AAQ89953 Human Omim: 300276 Human SwissProt: Q9HAV5 Human SwissProt: Q8BX35 Mouse Unigene: 302017 Human Unigene: 189270 Mouse |
| 產(chǎn)品圖片 |
Sample:
Lane 1: Human U-2 OS cell lysates
Lane 2: Human HepG2 cell lysates
Lane 3: Human U87MG cell lysates
Lane 4: Human 293T cell lysates
Primary: Anti-EDA2R (bs-25230R) at 1/1000 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 33 kDa
Observed band size: 36 kDa
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