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Rabbit Anti-EMILIN2  antibody (bs-14584R)  
~~~促銷代碼KT202411~~~
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產品編號 bs-14584R
英文名稱 Rabbit Anti-EMILIN2  antibody
中文名稱 彈性蛋白微原纖維界面因子2抗體
別    名 Elastin microfibril interface-located protein 2; Elastin microfibril interfacer 2; EMIL2_HUMAN; EMILIN-2; EMILIN2; extracellular glycoprotein EMILIN-2; FOAP-10; Protein FOAP-10.  
研究領域 細胞生物  發育生物學  信號轉導  糖蛋白  細胞外基質  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 (predicted: Human,Mouse,Rat,Rabbit,Pig,Sheep,Cow,Dog,Horse)
產品應用 WB=1:500-2000,IHC-P=1:100-500,IHC-F=1:100-500,ICC/IF=1:100-500,IF=1:100-500,ELISA=1:5000-10000
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理論分子量 112kDa
細胞定位 細胞漿 
性    狀 Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human EMILIN2: 251-350/1053 
亞    型 IgG
純化方法 affinity purified by Protein A
緩 沖 液 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存條件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事項 This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
產品介紹 EMILINs (elastin microfibril interface located proteins) are extracellular matrix glycoproteins that localize to sites with proximity to elastin and microfibrils. They consist of an N-terminal cysteine rich EMI domain and a conserved C-terminal gC1q-like domain. EMILIN-1 is abundant in elastin-rich tissues such as blood vessels, skin, heart and lung. It influences placenta formation and initial organogenesis with a later role in interstitial connective tissue. EMILIN-2 is larger than EMILIN-1 and contains a unique proline-rich domain. It is likely involved in the process of elastogenesis. Multimerin-2 (also known as EMILIN-3 or EndoGlyx-1) is expressed during embryonic development. Multimerin-1 (also known as EMILIN-4) is expressed in platelets and the endothelium of blood vessels and may act as a carrier protein for platelet factor V. EMILIN-5 is encoded by the EMILIN3 gene and is sometimes referred to as EMILIN-3. It contains the N-terminal cysteine rich EMI domain but lacks the C-terminal gC1q-like domain. EMILIN-5 is expressed in human mesenchymal stem cells and plays an important role in skeletal development.

Function:
May be responsible for anchoring smooth muscle cells to elastic fibers, and may be involved not only in the formation of the elastic fiber, but also in the processes that regulate vessel assembly. Has cell adhesive capacity.

Subcellular Location:
Secreted > extracellular space > extracellular matrix. Found mainly at the interface between amorphous elastin and microfibrils.

Tissue Specificity:
Highest levels are present in fetal heart and adult lung. Intermediate levels in peripheral leukocytes, placenta, and spinal cord and low expression in fetal brain, spleen, thymus, and lung and in adult heart, aorta, testis, bone marrow, small intestine, thymus, lymph node, and appendix.

Similarity:
Contains 1 C1q domain.
Contains 1 collagen-like domain.
Contains 1 EMI domain.

SWISS:
Q9BXX0

Gene ID:
84034

Database links:

Entrez Gene: 84034 Human

SwissProt: Q9BXX0 Human

Unigene: 532815 Human



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