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Rabbit Anti-GLUT8  antibody (bs-4241R)  
~~~促銷代碼KT202411~~~
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產品編號 bs-4241R
英文名稱 Rabbit Anti-GLUT8  antibody
中文名稱 葡萄糖轉運蛋白8抗體
別    名 Glucose Transporter 8; Glucose transporter type 8; Glucose transporter type X1; GLUT-8; GLUT 8; GLUTX1; SLC2A8; solute carrier family 2 (facilitated glucose transporter) member 8.  
Specific References  (12)     |     bs-4241R has been referenced in 12 publications.
[IF=4.556] Yoichi Chiba. et al. Glucose, Fructose, and Urate Transporters in the Choroid Plexus Epithelium. Int J Mol Sci. 2020 Jan;21(19):7230  IHC ;  Human.  
[IF=4.232] Pawe? Jan Stanirowski. et al. Placental expression of glucose transporters GLUT-1, GLUT-3, GLUT-8 and GLUT-12 in pregnancies complicated by gestational and type 1 diabetes mellitus.. 2021 Sep 23  IHC ;  human.  
[IF=3.584] Lin, Guan-Yu. et al. Altered glucose metabolism and its association with carbonic anhydrase 8 in Machado-Joseph Disease. METAB BRAIN DIS. 2022 Apr;:1-18  IHC ;  Mouse.  
[IF=3.23] Maria Z, Campolo AR, Lacombe VA (2015) Diabetes Alters the Expression and Translocation of the Insulin-Sensitive Glucose Transporters 4 and 8 in the Atria. PLoS ONE 10(12): e0146033.  WB ;  Mouse.  
[IF=3.23] Jackson EE, Rendina-Ruedy E, Smith BJ, Lacombe VA (2015) Loss of Toll-Like Receptor 4 Function Partially Protects against Peripheral and Cardiac Glucose Metabolic Derangements During a Long-Term High-Fat Diet. PLoS ONE 10(11): e0142077.  WB ;  Mouse.  
[IF=3.05] Murakami, Ryuta, et al. "Immunoreactivity of glucose transporter 8 is localized in the epithelial cells of the choroid plexus and in ependymal cells." Histochemistry and Cell Biology (2016):1-6.  WB, IHC-P, IHC-F ;  Human, Mouse.  
[IF=2.923] Lei Shi. et al. Proteomic analysis reveals the potential positive effects of Mito-TEMPO on ram sperm motility and fertility during cryopreservation. THERIOGENOLOGY. 2023 Jul;205:27  WB ;  Sheep.  
[IF=2.59] Tian C et al. Short communication: A high-grain diet entails alteration in nutrient chemosensing of the rumen epithelium in goats. Animal Feed Science and Technology. Volume 262, April 2020, 114410.  IHC-P ;  
[IF=2.11] Mashima, Masato, et al. "Glucose transporter 8 immunoreactivity in astrocytic and microglial cells in subependymal areas of human brains." Neuroscience Letters (2016).  IHC-P ;  Human.  
[IF=1.974] Changxin Tian. et al. The expression of nutrient chemosensing gate molecules in the ileum and colon is altered for goats fed on a high-grain diet. ANIM SCI J. 2022 Jan;93(1):e13754  IHC ;  Goat.  
[IF=1.58] Gao, Sujie, et al. "Propofol inhibits growth of neurons through regulating insulin receptor and insulin-like growth factor-1 receptor." Int J Clin Exp Pathol 9.7 (2016): 6785-6794.  WB ;  Rat.  
[IF=1.273] Lei Shi. et al. Effects of reduced glutathione on ram sperm parameters, antioxidant status, mitochondrial activity and the abundance of hexose transporters during liquid storage at 5 ℃. Small Ruminant Res. 2020 Aug;189:106139  WB ;  Sheep.  
研究領域 腫瘤  免疫學  信號轉導  轉運蛋白  新陳代謝  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 Mouse,Rat (predicted: Human)
產品應用 WB=1:500-2000,ELISA=1:5000-10000
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理論分子量 52kDa
細胞定位 細胞漿 細胞膜 
性    狀 Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human GLUT8: 221-320/477 <Extracellular>
亞    型 IgG
純化方法 affinity purified by Protein A
緩 沖 液 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存條件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事項 This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
產品介紹 Glucose transporter 8 is an insulin-regulated facilitative glucose transporter. It binds cytochalasin B in a glucose-inhibitable manner. It appears to be a dual-specific sugar transporter as it can be inhibited by fructose. It is highly expressed in testis, where it is down-regulated by estrogen, but not in testicular carcinoma. Lower amounts are present in most other tissues.

Subunit:
Interacts with AP2B1.

Subcellular Location:
Cell membrane; Multi-pass membrane protein. Cytoplasmic vesicle membrane; Multi-pass membrane protein. Note=Principally intracellular. May move between intracellular vesicles and the plasma membrane. The dileucine internalization motif is critical for intracellular sequestration. Insulin induces a change in the intracellular localization and gives rise to insertion in the plasma membrane.

Tissue Specificity:
Highest level of expression in placenta and testis. Highly expressed in adult and pubertal testis, but not prepubertal testis. Lower levels of expression in brain, liver, heart, kidney, fat and skeletal muscle.

Similarity:
Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose transporter subfamily.

SWISS:
Q9NY64

Gene ID:
29988

Database links:

Entrez Gene: 29988 Human

Entrez Gene: 56017 Mouse

Entrez Gene: 85256 Rat

Omim: 605245 Human

SwissProt: Q9NY64 Human

SwissProt: Q9JIF3 Mouse

SwissProt: Q9JJZ1 Rat

Unigene: 179522 Human

Unigene: 305754 Mouse

Unigene: 12923 Rat



產品圖片
Sample: TM4 Cell (Mouse) Lysate at 40 ug Primary: Anti- GLUT8 (bs-4241R) at 1/300 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 52 kD Observed band size: 52 kD
Sample: Lane 1: Mouse Cerebrum tissue lysates Lane 2: Rat Cerebrum tissue lysates Primary: Anti-GLUT8 (bs-4241R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 52 kDa Observed band size: 52 kDa
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