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Rabbit Anti-POGZ/ZNF635/RBITC Conjugated antibody (bs-12753R-RBITC)
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說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產品編號 bs-12753R-RBITC
英文名稱1 Rabbit Anti-POGZ/ZNF635/RBITC Conjugated antibody
中文名稱 羅丹明(RBITC)標記的鋅指蛋白635抗體
別    名 KIAA0461; MGC71543; Pogo transposable element with ZNF domain; POGZ; POGZ_HUMAN; putative protein product of Nbla00003; SUHW5; suppressor of hairy wing homolog; Suppressor of hairy wing homolog 5; Zinc finger protein 280E; Zinc finger protein 635; ZNF280E; ZNF635; ZNF635M.  
規格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
研究領域 細胞生物  轉錄調節因子  鋅指蛋白  表觀遺傳學  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 (predicted: Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit, Sheep, )
產品應用 ICC=1:50-200 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 155kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human POGZ/ZNF
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產品介紹 background:
The protein encoded by this gene appears to be a zinc finger protein containing a transposase domain at the C-terminus. This protein was found to interact with the transcription factor SP1 in a yeast two-hybrid system. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Aug 2010]

Function:
Plays a role in mitotic cell cycle progression and is involved in kinetochore assembly and mitotic sister chromatid cohesion. Probably through its association with CBX5 plays a role in mitotic chromosome segregation by regulating aurora kinase B/AURKB activation and AURKB and CBX5 dissociation from chromosome arms.

Subcellular Location:
Nucleus. Chromosome. Cytoplasm. According to some authors, it is not localized to mitotic chromatin (PubMed:19244240). Recruited to trimethylated 'Lys-9' of histone H3.

Similarity:
Contains 9 C2H2-type zinc fingers.
Contains 1 DDE domain.
Contains 1 HTH CENPB-type DNA-binding domain.

Database links:

Entrez Gene: 475849 Dog

Entrez Gene: 23126 Human

Entrez Gene: 229584 Mouse

Entrez Gene: 310658 Rat

Omim: 614787 Human

SwissProt: Q7Z3K3 Human

SwissProt: Q8BZH4 Mouse

Unigene: 489873 Human

Unigene: 274787 Mouse

Unigene: 103975 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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