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Rabbit Anti-REPS2/RBITC Conjugated antibody (bs-19834R-RBITC)
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說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產品編號 bs-19834R-RBITC
英文名稱1 Rabbit Anti-REPS2/RBITC Conjugated antibody
中文名稱 羅丹明(RBITC)標記的REPS2蛋白抗體
別    名 OTTHUMP00000022995; Partner of Ral binding protein 1; Partner of RalBP1; POB1; RALBP1 associated Eps domain containing 2; RALBP1 interacting protein 2; RALBP1-associated Eps domain-containing protein 2; REPS 2. REPS2_HUMAN  
規格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
研究領域 腫瘤  細胞生物  染色質和核信號  信號轉導  G蛋白信號  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 (predicted: Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, )
產品應用 ICC=1:50-200 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 66kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human REPS2
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產品介紹 background:
The product of this gene is part of a protein complex that regulates the endocytosis of growth factor receptors. The encoded protein directly interacts with a GTPase activating protein that functions downstream of the small G protein Ral. Its expression can negatively affect receptor internalization and inhibit growth factor signaling. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Function:
Involved in growth factor signaling through its influence on the Ral signaling pathway.

Subunit:
Interacts with ASAP1 and this complex can bind paxillin. May form a ternary complex with RALBP1 and ASAP1 (By similarity). Interacts with RALBP1 and GRB2. Binding to RALBP1 does not affect the Ral-binding activity of the latter. It can form a ternary complex with activated Ral and RALBP1. Binds EPN1.

Subcellular Location:
Cytoplasmic.

Tissue Specificity:
Expressed at high levels in the cerebrum, cerebellum, lung, kidney, and testis. Weakly expressed in the kidney. Relatively highly expressed in androgen-dependent as compared to androgen-independent prostate cancer cell lines and xenografts. Isoform 2 is down-regulated during progression of prostate cancer.

Post-translational modifications:
EGF stimulates phosphorylation on Tyr-residues and induces complex formation with EGF receptor through an adapter protein such as GRB2.

Similarity:
Contains 1 EF-hand domain.
Contains 2 EH domains.

Database links:

Entrez Gene: 526887 Cow

Entrez Gene: 100056954 Horse

Entrez Gene: 9185 Human

Entrez Gene: 100353871 Rabbit

Entrez Gene: 363466 Rat

Omim: 300317 Human

SwissProt: Q8NFH8 Human

Unigene: 186810 Human

Unigene: 207682 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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