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Rabbit Anti-MFSD1/BF594 Conjugated antibody (bs-18898R-BF594)
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說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產品編號 bs-18898R-BF594
英文名稱1 Rabbit Anti-MFSD1/BF594 Conjugated antibody
中文名稱 BF594標記的平滑肌細胞相關蛋白4抗體
別    名 FLJ14153; Major facilitator superfamily domain containing 1; Major facilitator superfamily domain-containing protein 1; MFSD1; MFSD1_HUMAN; SMAP 4; SMAP-4; SMAP4; Smooth muscle cell-associated protein 4; UG0581B09.  
規格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
研究領域 腫瘤  細胞生物  細胞膜蛋白  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 (predicted: Human, Mouse, Rat, Horse, Sheep, )
產品應用 ICC=1:50-200 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 51kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human MFSD1
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產品介紹 background:
MFSD1 is a 465 amino acid multi-pass membrane protein that exists as two isoforms as a result of alternative splicing events. A related protein, MFSD2, may play a role in placenta morphogenesis and may also be involved in adaptive thermogenesis. The gene encoding MFSD1 maps to human chromosome 3, which is made up of about 214 million bases encoding over 1,100 genes, including a chemokine receptor (CKR) gene cluster and a variety of human cancer-related gene loci. Marfan Syndrome, porphyria, von Hippel-Lindau syndrome, osteogenesis imperfecta and Charcot-Marie-Tooth Disease are a few of the numerous genetic diseases associated with chromosome 3.

Function:
May play a role in eye development.

Subcellular Location:
Membrane; Single-pass type II membrane protein

Tissue Specificity:
Specifically expressed in brain. Strongly expressed in medulla oblongata and to a lower extent in hippocampus and corpus callosum. Expressed in keratinocytes.

DISEASE:
Nanophthalmos 2 (NNO2) [MIM:609549]: Rare autosomal recessive disorder of eye development characterized by extreme hyperopia and small functional eyes. Note: The disease is caused by mutations affecting the gene represented in this entry. Ref.8
Microphthalmia, isolated, 5 (MCOP5) [MIM:611040]: A disorder characterized by posterior microphthalmia, retinitis pigmentosa, foveoschisis and optic disk drusen. Microphthalmia is a disorder of eye formation, ranging from small size of a single eye to complete bilateral absence of ocular tissues. Ocular abnormalities like opacities of the cornea and lens, scaring of the retina and choroid, and other abnormalities may also be present.
Note: The disease is caused by mutations affecting the gene represented in this entry.

Similarity:
Contains 2 CUB domains.
Contains 1 FZ (frizzled) domain.
Contains 2 LDL-receptor class A domains.

Database links:

Entrez Gene: 64747 Human

Entrez Gene: 66868 Mouse

Entrez Gene: 361957 Rat

Entrez Gene: 641486 Zebrafish

SwissProt: Q9H3U5 Human

SwissProt: Q9DC37 Mouse

SwissProt: Q32LQ6 Zebrafish

Unigene: 58663 Human

Unigene: 271975 Mouse

Unigene: 391791 Rat

Unigene: 121245 Zebrafish



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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