| 產(chǎn)品編號 | bs-17861R-BF488 |
| 英文名稱1 | Rabbit Anti-MSRB2/BF488 Conjugated antibody |
| 中文名稱 | BF488標(biāo)記的蛋氨酸亞砜還原酶B2抗體 |
| 別 名 | CBS 1; CBS1; CGI 131; Methionine sulfoxide reductase B2; Methionine-R-sulfoxide reductase B2; MGC26104; mitochondrial; MSRB 2; MSRB; Msrb2; MSRB2_HUMAN; PILB; Pilin like transcription factor. |
| 規(guī)格價(jià)格 | 100ul/2980元 購買 大包裝/詢價(jià) |
| 說 明 書 | 100ul |
| 研究領(lǐng)域 | 腫瘤 細(xì)胞生物 免疫學(xué) 信號轉(zhuǎn)導(dǎo) 新陳代謝 線粒體 |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | (predicted: Human, Mouse, Rat, Dog, Horse, ) |
| 產(chǎn)品應(yīng)用 | ICC=1:50-200 IF=1:50-200
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 20kDa |
| 性 狀 | Lyophilized or Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human MSRB2 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 儲 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol |
| 保存條件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 產(chǎn)品介紹 |
background: Methionine is one of the most readily oxidized essential amino acids and an intermediate in the biosynthesis of cysteine, carnitine, taurine, lecithin, phosphatidylcholine and other phospholipids. In its oxidative state, Methionine is regulated in vivo by methionine sulfoxide reductases (Msr). MsrB2 is a 182 amino acid mitochondrial protein that is ubiquitously expressed. Belonging to the MsrB Met sulfoxide reductase family, MsrB2 acts as a catalyst for the reduction of free and protein-bound methionine sulfoxide to methionine. Upon oxidative stress, MsrB2 is suggested to play a role in the preservation of mitochondrial integrity by decreasing the intracellular reactive oxygen species build-up through its scavenging role, hence contributing to cell survival and protein maintenance. MsrB2 utilizes zinc ions, one per subunit, as cofactors. Function: Methionine-sulfoxide reductase that specifically reduces methionine (R)-sulfoxide back to methionine. While in many cases, methionine oxidation is the result of random oxidation following oxidative stress, methionine oxidation is also a post-translational modification that takes place on specific residue. Upon oxidative stress, may play a role in the preservation of mitochondrial integrity by decreasing the intracellular reactive oxygen species build-up through its scavenging role, hence contributing to cell survival and protein maintenance. Subcellular Location: Mitochondrion. Tissue Specificity: Ubiquitous. Detected in retina, ocular ciliary body, skeletal muscle, heart, colon, bone marrow, cerebellum, small intestine, fetal brain, fetal liver, kidney, spinal cord, lung, placenta and prostate. Similarity: Belongs to the MsrB Met sulfoxide reductase family. Database links: Entrez Gene: 22921 Human Omim: 613782 Human SwissProt: Q9Y3D2 Human Unigene: 461420 Human Unigene: 23802 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
