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Rabbit Anti-ETEA/Gold Conjugated antibody (bs-13109R-Gold)
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說 明 書: 100ul(10nm  15nm  35nm
100ul/2980.00元
大包裝/詢價
產品編號 bs-13109R-Gold
英文名稱1 Rabbit Anti-ETEA/Gold Conjugated antibody
中文名稱 膠體金標記的T細胞和嗜酸性粒細胞表達特應性皮炎蛋白ETEA抗體
別    名 AI462440; expressed in T cells and eosinophils in atopic dermatitis; faf2; FAF2_HUMAN; Fas associated factor family member 2; FAS-associated factor 2; KIAA0887; Protein ETEA; Protein expressed in T cells and eosinophils in atopic dermatitis; Protein expressed in T-cells and eosinophils in atopic dermatitis; UBX domain containing 8; UBX domain protein 3B; UBX domain-containing protein 3B; UBX domain-containing protein 8; UBXD8; UBXN3B.  
規格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul(10nm  15nm  35nm
研究領域 細胞生物  細胞凋亡  淋巴細胞  t-淋巴細胞  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 (predicted: Human, Mouse, Rat, Chicken, Horse, Sheep, )
產品應用 IEM=1:20-200 ICA=1:20-200 ChIP=1:20-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 53kDa
性    狀 Lyophilized or Liquid
濃    度 0.4mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human ETEA
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.02M TBS(pH8.2) with 1% BSA, 0.03% Proclin300.
保存條件 Store at 2-8 oC for 3-6 months. Avoid repeated freeze/thaw cycles.
產品介紹 background:
ETEA is a 445-amino acid protein associated with atopic dermatitis (AD), a chronic noncontagious relapsing inflammatory skin disease characterized by eczematous skin lesions and also referred to as eczematous dermatitis. Other atopic diseases such as hay fever, asthma and conjunctivitis often occur along with AD. ETEA shows higher expression in T cells and eosinophils of patients with AD than in T cells and eosinophils of unaffected individuals. T cells are influential in the regulation of the inflammatory process of this disease. The persistence of jAD is attributed to dysregulated apoptosis in T cells, eosinophils, and keratinocytes. ETEA may be involved in the resistance to apoptosis in T cells and eosinophils of AD patients.

Function:
May play a role in the translocation of terminally misfolded proteins from the endoplasmic reticulum lumen to the cytoplasm and their degradation by the proteasome.

Subunit:
Identified in a complex that contains SEL1L, OS9, FAF2/UBXD8, UBE2J1/UBC6E and AUP1. Interacts with YOD1.

Subcellular Location:
Cytoplasm. Lipid droplet. Endoplasmic reticulum.

Tissue Specificity:
Broadly expressed, with highest levels in brain.

Similarity:
Contains 1 UBX domain.

Database links:
UniProtKB/Swiss-Prot: Q96CS3.2

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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