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Rabbit Anti-TACC2/PE Conjugated antibody (bs-5736R-PE)
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說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產品編號 bs-5736R-PE
英文名稱1 Rabbit Anti-TACC2/PE Conjugated antibody
中文名稱 PE標記的轉化酸性卷曲含蛋白質2
別    名 TACC2_HUMAN; Anti zuai 1; AZU 1; AZU1; ECTACC; TACC 2; Transforming acidic coiled coil containing protein 2.   
規格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
研究領域 腫瘤  細胞生物  免疫學  細胞周期蛋白  細胞分化  細胞類型標志物  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 (predicted: Human, Mouse, Rat, Dog, Cow, Rabbit, )
產品應用 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 309kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human TACC2
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產品介紹 background:
TACC2 is a conserved family of centrosome and microtubule interacting proteins that are implicated in cancer. This gene encodes a protein that concentrates at centrosomes throughout the cell cycle. This gene lies within a chromosomal region associated with tumorigenesis. Expression of this gene is thought to affect the progression of breast tumors. Expression of this gene is also induced by erythropoietin.

Function:
Plays a role in the microtubule-dependent coupling of the nucleus and the centrosome. Involved in the processes that regulate centrosome-mediated interkinetic nuclear migration (INM) of neural progenitors (By similarity). May play a role in organizing centrosomal microtubules. May act as a tumor suppressor protein. May represent a tumor progression marker.

Subunit:
Interacts with CCDC100/CEP120 (By similarity). Interacts with microtubules. Interacts with YEATS4, GCN5L2 and PCAF.

Subcellular Location:
Cytoplasm. Nucleus. Cytoplasm, cytoskeleton, centrosome.

Tissue Specificity:
Strongly expressed in heart, skeletal muscle, brain, prostate, thyroid and trachea.

Post-translational modifications:
Phosphorylated by TTK; which is required for localization in centrosome.

Similarity:
Belongs to the TACC family.
Contains 1 SPAZ (Ser/Pro-rich AZU-1) domain.

Database links:
UniProtKB/Swiss-Prot: O95359.3

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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