| 產(chǎn)品編號(hào) | bs-7713R-BF488 |
| 英文名稱1 | Rabbit Anti-MIS12/BF488 Conjugated antibody |
| 中文名稱 | BF488標(biāo)記的染色體及有絲分裂蛋白MIS12抗體 |
| 別 名 | hMIS12; homolog of yeast Mis12; KNTC2AP; MIND kinetochore complex component, homolog (yeast); MIS12 homolog (yeast); MIS12 homolog; MIS12 MIND kinetochore complex component homolog (yeast); MTW 1; MTW1; Protein MIS12 homolog; MIS12_HUMAN. |
| 規(guī)格價(jià)格 | 100ul/2980元 購(gòu)買 大包裝/詢價(jià) |
| 說(shuō) 明 書(shū) | 100ul |
| 研究領(lǐng)域 | 細(xì)胞生物 細(xì)胞周期蛋白 細(xì)胞分化 表觀遺傳學(xué) |
| 抗體來(lái)源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | (predicted: Human, Mouse, Rat, Dog, Cow, Horse, Sheep, ) |
| 產(chǎn)品應(yīng)用 | IF=1:50-200
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 24kDa |
| 性 狀 | Lyophilized or Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from humna MIS12 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 儲(chǔ) 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol |
| 保存條件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 產(chǎn)品介紹 |
background: MIS12 is part of a complex that plays an essential role in chromosome segregation in vertebrates and contributes to mitotic kinetochore assembly. Function: Part of the MIS12 complex which is required for normal chromosome alignment and segregation and for kinetochore formation during mitosis. Subunit: Component of the MIS12 complex composed of MIS12, DSN1, NSL1 and PMF1. Also interacts with CASC5, CBX3, CBX5, NDC80 and ZWINT. Subcellular Location: Nucleus. Chromosome, centromere, kinetochore. Note=Associated with the kinetochore. Similarity: Belongs to the mis12 family. Database links: UniProtKB/Swiss-Prot: Q9H081.1 Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 細(xì)胞周期是細(xì)胞最基本的生命活動(dòng)之一,它通過(guò)一系列有序的反應(yīng)進(jìn)行分裂,產(chǎn)生兩個(gè)包含相同遺傳物質(zhì)的子細(xì)胞。細(xì)胞周期中最核心的事件就是進(jìn)行遺傳物質(zhì)的復(fù)制和分離,即在S期進(jìn)行DNA的復(fù)制,然后在有絲分裂時(shí)期將復(fù)制的染色體平均分配到子細(xì)胞中去。有絲分裂過(guò)程中染色體的運(yùn)動(dòng)和分離又是通過(guò)紡錘體微管和位于染色體著絲粒上的動(dòng)點(diǎn)之間的協(xié)同作用來(lái)完成的。 MIS12是一個(gè)進(jìn)化上較為保守的蛋白復(fù)合物,人源MIS12復(fù)合物由Mis13、Mis14、Mis12和PMF1四個(gè)蛋白組成,功能性研究表明它們?cè)趧?dòng)點(diǎn)的組裝和染色體的分離中發(fā)揮重要作用,但是，目前它們動(dòng)點(diǎn)定位機(jī)制仍不清楚，還有待進(jìn)一步研究。 |
