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Rabbit Anti-KLF4/BF555 Conjugated antibody (bs-1064R-BF555)
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說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產品編號 bs-1064R-BF555
英文名稱1 Rabbit Anti-KLF4/BF555 Conjugated antibody
中文名稱 BF555標記的腸道內富含的Kruppel樣因子/上皮鋅指蛋白4抗體
別    名 Endothelial Kruppel like zinc finger protein; EZF; GKLF; KLF; Kruppel like factor 4 (Epithelial zinc finger protein EZF) (Gut enriched Krueppel like factor); Kruppel like factor 4 (gut); Krueppel-like factor 4;EZF;GKLF;KLF 4;KLF-4;Krueppel like factor 4; KLF4_HUMAN.  
規格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
研究領域 腫瘤  細胞生物  信號轉導  干細胞  細胞周期蛋白  轉錄調節因子  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 Human, Rat,  (predicted: Mouse, Chicken, Pig, Cow, Horse, Sheep, Guinea Pig, )
產品應用 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 56kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human KLF4
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產品介紹 background:
KLF4 is a transcription factor that works with Sp1 to activate the Laminin gamma1 chain gene. It binds the CACCC core sequence. KLF4 may be involved in the differentiation of epithelial cells and may also function in the development of the skeleton and kidney. KLF4 also has roles as both an oncogene and a tumor suppressor.

Function:
Transcription factor; can act both as activator and as repressor. Binds the 5'-CACCC-3' core sequence. Binds to the promoter region of its own gene and can activate its own transcription. Regulates the expression of key transcription factors during embryonic development. Plays an important role in maintaining embryonic stem cells, and in preventing their differentiation. Required for establishing the barrier function of the skin and for postnatal maturation and maintenance of the ocular surface. Involved in the differentiation of epithelial cells and may also function in skeletal and kidney development. Contributes to the down-regulation of p53/TP53 transcription.

Subunit:
Interacts with POU5F1/OCT4 and SOX2. Interacts with MUC1 (via the C-terminal domain).

Subcellular Location:
Nucleus.

Post-translational modifications:
Ubiquitinated. Polyubiquitination involves WWP1 and leads to proteasomal degradation of this protein.

Similarity:
Belongs to the krueppel C2H2-type zinc-finger protein family.
Contains 3 C2H2-type zinc fingers.

Database links:

Entrez Gene: 9314 Human

Entrez Gene: 16600 Mouse

Omim: 602253 Human

SwissProt: O43474 Human

SwissProt: Q60793 Mouse

Unigene: 376206 Human

Unigene: 4325 Mouse



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

Klf4(原稱GKLF)調節體外細胞的增生與分化,有學者認為:KLF4可能參與消化系統腫瘤的發生及發展過程,多表達與結腸。又稱:上皮鋅指轉錄因子(上皮鋅指蛋白)Surface skin layer zinc finger protein。
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