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Rabbit Anti-Involucrin/BF555 Conjugated antibody (bs-1236R-BF555)
訂購熱線:400-901-9800
訂購郵箱:sales@www.chomd.com.cn
訂購QQ:  400-901-9800
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說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產品編號 bs-1236R-BF555
英文名稱1 Rabbit Anti-Involucrin/BF555 Conjugated antibody
中文名稱 BF555標記的囊包蛋白/內披蛋白抗體
別    名 INVO_HUMAN; involucrin; ivl.  
規格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
研究領域 細胞生物  信號轉導  細胞周期蛋白  細胞骨架  細胞外基質  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 (predicted: Human, )
產品應用 ICC=1:50-200 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 64kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human Involucrin
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產品介紹 background:
Involucrin, a component of the keratinocyte crosslinked envelope, is found in the cytoplasm and crosslinked to membrane proteins by transglutaminase. This gene is mapped to 1q21, among calpactin I light chain, trichohyalin, profillaggrin, loricrin, and calcyclin. [provided by RefSeq, Jul 2008].

Function:
Part of the insoluble cornified cell envelope (CE) of stratified squamous epithelia.

Subunit:
Directly or indirectly cross-linked to cornifelin (CNFN).

Subcellular Location:
Cytoplasm.

Tissue Specificity:
Keratinocytes of epidermis and other stratified squamous epithelia.

Post-translational modifications:
Substrate of transglutaminase. Some glutamines and lysines are cross-linked to other involucrin molecules, to other proteins such as keratin, desmoplakin, periplakin and envoplakin, and to lipids like omega-hydroxyceramide.

Similarity:
Belongs to the involucrin family.

Database links:

Entrez Gene: 3713 Human

Entrez Gene: 16447 Mouse

Entrez Gene: 60583 Rat

Omim: 147360 Human

SwissProt: P07476 Human

SwissProt: P48997 Mouse

SwissProt: P48998 Rat

Unigene: 516439 Human

Unigene: 207365 Mouse

Unigene: 142591 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

套膜蛋白又稱內披蛋白或囊包蛋白,與毛透明蛋白共同構成角質細胞包膜支架的蛋白質。在角質細胞分化時,首先出現在表皮棘層的上層細胞中的標志性蛋白質,該蛋白在角質細胞和其他復層扁平上皮合成的蛋白。最初存在于細胞質中,然后通過轉谷氨酰胺酶的作用,轉變為交聯的膜蛋白。
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