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Rabbit Anti-Phospho-PRK1 (Thr774) + PRK2 (Thr816) + PRK3 (Thr718)/Cy5.5 Conjugated antibody (bs-3347R-Cy5.5)
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說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產品編號 bs-3347R-Cy5.5
英文名稱1 Rabbit Anti-Phospho-PRK1 (Thr774) + PRK2 (Thr816) + PRK3 (Thr718)/Cy5.5 Conjugated antibody
中文名稱 Cy5.5標記的磷酸化內分泌腺衍生血管內皮生長因子抗體
別    名 PRK3+PRK2+PRK1 (phospho T816 + T718 + T774); PROK1; Prokineticin-1/Endocrine-gland-derived vascular endothelial growth factor; EGVEGF; PK1; EG-VEGF; EG VEGF; PRK1; Prokineticin 1; Black mamba toxin related; Endocrine gland derived vascular endothelial growth factor; Endocrine-gland-derived vascular endothelial growth factor; Mambakine; PROK1_HUMAN; Cardiolipin activated protein kinase Pak2; PAK 2; PAK2; PKN gamma; PKN2; PKN2_HUMAN; PRK2; PRKCL2; PRO2042; Protein kinase C like 2; Protein kinase C related kinase 2; Protein kinase C-like 2; Protein kinase N2; Protein-kinase C-related kinase 2; Serine/threonine-protein kinase N2.  
規格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
產品類型 磷酸化抗體 
研究領域 腫瘤  免疫學  血管內皮細胞  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 (predicted: Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, )
產品應用 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 103kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthesised phosphopeptide derived from human PRK1 around the phosphorylation site of Thr774
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產品介紹 background:
The protein encoded by this gene induces proliferation, migration, and fenestration (the formation of membrane discontinuities) in capillary endothelial cells derived from endocrine glands. It has little or no effect on a variety of other endothelial and non-endothelial cell types. Its expression is restricted to the steroidogenic glands (ovary, testis, adrenal, and placenta), is induced by hypoxia, and often complementary to the expression of vascular endothelial growth factor (VEGF), suggesting that these molecules function in a coordinated manner. [provided by RefSeq, Sep 2011]

Function:
Potently contracts gastrointestinal (GI) smooth muscle. Induces proliferation, migration and fenestration (the formation of membrane discontinuities) in capillary endothelial cells derived from endocrine glands. Has little or no effect on a variety of other endothelial and non-endothelial cell types. Induces proliferation and differentiation, but not migration, of enteric neural crest cells. Directly influences neuroblastoma progression by promoting the proliferation and migration of neuroblastoma cells. Positively regulates PTGS2 expression and prostaglandin synthesis. May play a role in placentation. May play a role in normal and pathological testis angiogenesis.

Subcellular Location:
Secreted.

Tissue Specificity:
Localizes to glandular epithelium, stroma and vascular epithelial cells of first trimester decidua (at protein level). Up-regulated in first trimester decidua when compared with non-pregnant endometrium. Expressed in the steroidogenic glands, ovary, testis, adrenal and placenta.

Similarity:
Belongs to the AVIT (prokineticin) family.

Database links:

Entrez Gene: 84432 Human

Entrez Gene: 246691 Mouse

Entrez Gene: 192205 Rat

Omim: 606233 Human

SwissProt: P58294 Human

SwissProt: Q14A28 Mouse

SwissProt: Q8R414 Rat

Unigene: 514793 Human

Unigene: 461353 Mouse

Unigene: 82757 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

EG-VEGF是先被發現的組織特異性促血管生成因子,與多種特定組織腫瘤的發生及演進相關,EG-VEGF多在卵巢、睪丸、腎上腺、胎盤等類固醇合成組織中高表達。
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