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Rabbit Anti-Phospho-Histone H3 (Ser28)/APC Conjugated antibody (bs-3187R-APC)
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說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產品編號 bs-3187R-APC
英文名稱1 Rabbit Anti-Phospho-Histone H3 (Ser28)/APC Conjugated antibody
中文名稱 APC標記的磷酸化組蛋白H3抗體
別    名 Histone H3 (phospho S28); p-Histone H3 (phospho S28); Phospho-Histone H3(Ser28); Histone H3(Phospho-Ser28); Histone H3(p-Ser28); Histone H3.3 (phospho S28); Histone H3(Phospho-S28); H3 histone family member E pseudogene; H3F3; HIST3H3; Histone H3 3 pseudogene; H31_TETTH; Histone H3; H3S; Histone H3-I/H3-II; Major histone H3; H3F; Histone H3/a; Histone H3/b; Histone H3/c; Histone H3/d; Histone H3/f; Histone H3/h; Histone H3/i; Histone H3/j; Histone H3/k; Histone H3/l.  
規格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
產品類型 磷酸化抗體 
研究領域 腫瘤  免疫學  染色質和核信號  信號轉導  轉錄調節因子  表觀遺傳學  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 Human,  (predicted: Mouse, Rat, Pig, Cow, Rabbit, Fruit Fly, )
產品應用 Flow-Cyt=1:50-200 ICC=1:50-200 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 15kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated Synthesised phosphopeptide derived from human Histone H3 around the phosphorylation site of Ser28
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產品介紹 background:
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. This structure consists of approximately 146 bp of DNA wrapped around a nucleosome, an octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a member of the histone H3 family. Transcripts from this gene lack polyA tails; instead, they contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6p22-p21.3. [provided by RefSeq, Jul 2008]

Function:
Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. H3 is deposited into chromatin exclusively through a DNA replication-coupled pathway that can be associated with either DNA duplication or DNA repair synthesis during meiotic homologous recombination.

Subunit:
The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. Interacts with GCN5, whereby H3S10ph increases histone-protein interactions. Interacts with PDD1 and PDD3.

Subcellular Location:
Nucleus. Chromosome. Note=Localizes to both the large, transcriptionally active, somatic macronucleus (MAC) and the small, transcriptionally inert, germ line micronucleus (MIC).

Post-translational modifications:
Phosphorylated to form H3S10ph. H3S10ph promotes subsequent H3K14ac formation by GCN5. H3S10ph is only found in the mitotically dividing MIC, but not in the amitotically dividing MAC. H3S10ph is correlated with chromosome condensation during mitotic or meiotic micronuclear divisions.
Acetylation of histone H3 leads to transcriptional activation. H3K14ac formation by GCN5 is promoted by H3S10ph. H3K9acK14ac is the preferred acetylated form of newly synthesized H3. Acetylation occurs almost exclusively in the MAC.
Methylated to form H3K4me. H3K4me is only found in the transcriptionally active MAC. Methylated to form H3K9me in developing MACs during conjugation, when genome-wide DNA elimination occurs. At this stage, H3K9me specifically occurs on DNA sequences being eliminated (IES), probably targeted by small scan RNAs (scnRNAs) bound to IES, and is required for efficient IES elimination. H3K9me is required for the interaction with the chromodomains of PDD1 and PDD3.
The full-length protein H3S (slow migrating) is converted to H3F (fast migrating) by proteolytic removal of the first 6 residues. H3F is unique to MIC, and processing seems to occur regularly each generation at a specific point in the cell cycle.

Similarity:
Belongs to the histone H3 family.

Database links:

Entrez Gene: 8290 Human

Entrez Gene: 8350 Human

Entrez Gene: 8351 Human

Entrez Gene: 8352 Human

Entrez Gene: 8353 Human

Entrez Gene: 8354 Human

Entrez Gene: 8355 Human

Entrez Gene: 8356 Human

Entrez Gene: 8357 Human

Entrez Gene: 8358 Human

Entrez Gene: 8968 Human

Entrez Gene: 260423 Mouse

Entrez Gene: 319148 Mouse

Entrez Gene: 319149 Mouse

Entrez Gene: 319150 Mouse

Entrez Gene: 319151 Mouse

Entrez Gene: 319152 Mouse

Entrez Gene: 319153 Mouse

Entrez Gene: 360198 Mouse

Entrez Gene: 97908 Mouse

Entrez Gene: 100364501 Rat

Entrez Gene: 100365669 Rat

Entrez Gene: 291159 Rat

Entrez Gene: 314977 Rat

Entrez Gene: 364716 Rat

Entrez Gene: 679950 Rat

Entrez Gene: 679994 Rat

Entrez Gene: 680511 Rat

Entrez Gene: 680599 Rat

Entrez Gene: 682330 Rat

Entrez Gene: 691496 Rat

Omim: 601128 Human

Omim: 602810 Human

Omim: 602811 Human

Omim: 602812 Human

Omim: 602813 Human

Omim: 602814 Human

Omim: 602815 Human

Omim: 602816 Human

Omim: 602817 Human

Omim: 602818 Human

Omim: 602819 Human

SwissProt: P68431 Human

SwissProt: P84243 Human

SwissProt: Q16695 Human

SwissProt: Q6NXT2 Human

SwissProt: Q71DI3 Human

SwissProt: P68433 Mouse

SwissProt: P84228 Mouse

SwissProt: Q6LED0 Rat

Unigene: 132854 Human

Unigene: 247813 Human

Unigene: 247814 Human

Unigene: 248176 Human

Unigene: 443021 Human

Unigene: 484990 Human

Unigene: 532144 Human

Unigene: 533292 Human

Unigene: 546315 Human

Unigene: 586261 Human

Unigene: 591778 Human

Unigene: 221301 Mouse

Unigene: 261657 Mouse

Unigene: 377874 Mouse

Unigene: 390558 Mouse

Unigene: 397328 Mouse

Unigene: 138090 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

蛋白的基因非常保守,在親緣關系較遠的種屬中, 四種組蛋白(H2A、H2A、H3、H4)氨基酸序列都非常相似, 如海膽組織H3的氨基酸序列與來自小牛胸腺的H3的氨基酸序列間只有一個氨基酸的差異, 小牛胸腺的H3的氨基酸序列與豌豆的H3也很相似。組蛋白是細胞核內的一種堿性核蛋白,抗組蛋白抗體即是以組蛋白為靶抗原的一種自身,是抗核抗體的一種.主要與藥物性紅斑狼瘡、系統性紅斑狼瘡、類風濕關節炎有關
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