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Rabbit Anti-NARC1/PCSK9/APC Conjugated antibody (bs-6060R-APC)
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說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產品編號 bs-6060R-APC
英文名稱1 Rabbit Anti-NARC1/PCSK9/APC Conjugated antibody
中文名稱 APC標記的神經細胞凋亡調節轉化蛋白1/前蛋白轉化酶枯草溶菌素9抗體
別    名 FH3; HCHOLA3; Hypercholesterolemia autosomal dominant 3; NARC 1; NARC-1; NARC1; Neural apoptosis regulated convertase 1; Neural apoptosis-regulated convertase 1; PC 9; PC9; PCSK 9; PCSK9; PCSK9_HUMAN; Proprotein convertase 9; Proprotein convertase PC9; Proprotein convertase subtilisin/kexin type 9; PSEC0052; Subtilisin/kexin like protease PC9; Subtilisin/kexin-like protease PC9.  
規格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
研究領域 心血管  細胞生物  免疫學  神經生物學  信號轉導  干細胞  細胞凋亡  轉錄調節因子  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 Mouse, Rat,  (predicted: Human, )
產品應用 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 57kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human PCSK9/NARC1
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產品介紹 background:
May be implicated in the differentiation of cortical neurons and may play a role in cholesterol homeostasis.

Function:
The precursor protein but not the mature protein may form multimers.

Subunit:
The precursor protein but not the mature protein may form multimers.

Subcellular Location:
Secreted.

Tissue Specificity:
Expressed in neuro-epithelioma, colon carcinoma, hepatic and pancreatic cell lines, and in Schwann cells.

Post-translational modifications:
The soluble zymogen undergoes autocatalytic intramolecular processing in the endoplasmic reticulum, resulting in the cleavage of its propeptide that remains associated with the secreted enzyme.

Similarity:
Belongs to the peptidase S8 family.
Contains 1 peptidase S8 domain.

Database links:

Entrez Gene: 255738 Human

Entrez Gene: 100102 Mouse

Entrez Gene: 298296 Rat

Omim: 607786 Human

SwissProt: Q8NBP7 Human

SwissProt: Q80W65 Mouse

SwissProt: P59996 Rat

Unigene: 18844 Human

Unigene: 133268 Mouse

Unigene: 19195 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

前蛋白轉化酶枯草溶菌素9(PCSK9)是近年來新發現的一種與調節脂質代謝密切相關的基因,編碼前蛋白轉化酶NARC-1。Narc-1/pcsk9可通過調節細胞表面的低密度脂蛋白受體(LDLR)水平,參與脂質代謝,從而在動脈粥樣硬化性疾病的發生、發展中發揮重要作用。
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