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Rabbit Anti-Synaptotagmin 1/SYT1  antibody (bs-21519R)  
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產品編號 bs-21519R
英文名稱 Rabbit Anti-Synaptotagmin 1/SYT1  antibody
中文名稱 突觸結合蛋白1抗體
別    名 DKFZp781D2042; P65; SVP65; Synaptotagmin I; SYT1_HUMAN; Synaptotagmin II; Synaptotagmin IV; Synaptotagmin V; SYT 1; SYT; SYT1; SYT2; SYT3; SYT4; SYT5; SytI.   
Specific References  (1)     |     bs-21519R has been referenced in 1 publications.
[IF=3.617] Ru-Meng Wei. et al. Altered cognition and anxiety in adolescent offspring whose mothers underwent different-pattern maternal sleep deprivation, and cognition link to hippocampal expressions of Bdnf and Syt-1. FRONT BEHAV NEUROSCI. 2022; 16: 1066725  WB ;  Mouse.  
研究領域 腫瘤  免疫學  神經生物學  信號轉導  細胞粘附分子  新陳代謝  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 Mouse (predicted: Human,Rat,Rabbit,Sheep,Cow,Chicken,Horse)
產品應用 WB=1:500-2000,ELISA=1:5000-10000
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理論分子量 48kDa
細胞定位 細胞外基質 分泌型蛋白 
性    狀 Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human Synaptotagmin 1/SYT1: 61-160/422 <Cytoplasmic>
亞    型 IgG
純化方法 affinity purified by Protein A
緩 沖 液 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存條件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事項 This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
產品介紹 The synaptotagmins are integral membrane proteins of synaptic vesicles thought to serve as Ca(2+) sensors in the process of vesicular trafficking and exocytosis. Calcium binding to synaptotagmin participates in triggering neurotransmitter release at the synapse. The first C2 domain mediates Ca(2+)-dependent phospholipid binding. The second C2 domain mediates interaction with Stonin 2. Synaptotagmin may have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse. It binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone. A Ca(2+)-dependent interaction between synaptotagmin and putative receptors for activated protein kinase C has also been reported. It can bind to at least three additional proteins in a Ca(2+)-independent manner; these are neurexins, syntaxin and AP2.

Function:
Cell adhesion protein that promotes adhesion and outgrowth of hippocampal embryonic neurons. Binds directly to bacteria and their components and functions as an opsonin for macrophage phagocytosis of bacteria. Essential in the initiation of the innate immune response and represents a unique pattern-recognition molecule in the ECM for microbial pathogens (By similarity). Binds bacterial lipopolysaccharide (LPS).

Subunit:
Homotetramer (Probable). Interacts with SCAMP5, STON2, SV2A, SV2B, SV2C and RIMS1. Forms a complex with SV2B, syntaxin 1 and SNAP25

Subcellular Location:
Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane; Single-pass membrane protein. Cytoplasmic vesicle, secretory vesicle, chromaffin granule membrane; Single-pass membrane protein. Cytoplasm. Note=Synaptic vesicles and chromaffin granules.

Similarity:
Belongs to the synaptotagmin family.
Contains 2 C2 domains.

SWISS:
P21579

Gene ID:
6857

Database links:

Entrez Gene: 6857 Human

Entrez Gene: 20979 Mouse

Entrez Gene: 25716 Rat

Omim: 185605 Human

SwissProt: P21579 Human

SwissProt: P46096 Mouse

SwissProt: P21707 Rat

Unigene: 310545 Human

Unigene: 289702 Mouse

Unigene: 216272 Rat



產品圖片
Sample: Cerebrum (Mouse) Lysate at 40 ug Cerebellum (Mouse) Lysate at 40 ug Primary: Anti-Synaptotagmin 1’SYT1 (bs-21519R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 48 kD Observed band size: 48 kD
Sample: Cerebral cortex (Mouse) Lysate at 40 ug Cerebrum (Mouse) Lysate at 40 ug Primary: Anti-Synaptotagmin 1’SYT1 (bs-21519R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 48 kD Observed band size: 48 kD
Sample: Cerebellum (Mouse) Lysate at 40 ug Primary: Anti-Synaptotagmin 1’SYT1 (bs-21519R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 48 kD Observed band size: 48 kD
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