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Mouse Anti-FASN  antibody (bsm-51155M)  
~~~促銷代碼KT202411~~~
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產品編號 bsm-51155M
英文名稱 Mouse Anti-FASN  antibody
中文名稱 脂肪酸合成酶單克隆抗體
別    名 fatty acid synthase; FASN; FAS; FA Synthase 1; MGC14367; MGC15706; OA-519; Fatty acid synthase; [Acyl-carrier-protein] S-acetyltransferase; [Acyl-carrier-protein] S-malonyltransferase; 3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase; 3-oxoacyl-[acyl-carrier-protein] reductase; 3-oxoacyl-[acyl-carrier-protein] synthase; Enoyl-[acyl-carrier-protein] reductase; Oleoyl-[acyl-carrier-protein] hydrolase; FAS_MHUMAN.  
Specific References  (3)     |     bsm-51155M has been referenced in 3 publications.
[IF=3.654] Yingjun Zhou. et al. Chrysin improves diabetic nephropathy by regulating the AMPK-mediated lipid metabolism in HFD/STZ-induced DN mice. J FOOD BIOCHEM. 2022 Aug;:e14379  WB ;  Mouse.  
[IF=3.448] Yang X et al. miR‐760 exerts an antioncogenic effect in esophageal squamous cell carcinoma by negatively driving fat metabolism via targeting c‐Myc. J Cell Biochem. 2019 Nov 10.  WB ;  Human.  
[IF=3.231] Jing Fan. et al. Chitosan Oligosaccharide Inhibits the Synthesis of Milk Fat in Bovine Mammary Epithelial Cells through AMPK-Mediated Downstream Signaling Pathway. ANIMALS. 2022 Jan;12(13):1692  WB ;  Bovine.  
研究領域 腫瘤  心血管  免疫學  神經生物學  信號轉導  合成與降解  
抗體來源 Mouse
克隆類型 Monoclonal
克 隆 號 2C5
交叉反應 Human (predicted: Mouse)
產品應用 WB=1:500-5000,IHC-P=1:100-500,IHC-F=1:20-200,ICC/IF=1:100-500,IF=1:20-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理論分子量 274kDa
細胞定位 細胞漿 
性    狀 Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human FASN 
亞    型 IgM
純化方法 affinity purified by Protein AGL
緩 沖 液 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存條件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事項 This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
產品介紹 FASN (Fatty Acid Synthase) is a central enzyme in de novo lipogenesis. FAS is a target for SREBP and is upregulated by LXR activation; it is also one of the accepted markers for insulin resistance, SREBP and LXR activation.

Function:
Fatty acid synthetase catalyzes the formation of long-chain fatty acids from acetyl-CoA, malonyl-CoA and NADPH. This multifunctional protein has 7 catalytic activities and an acyl carrier protein.

Subunit:
Homodimer which is arranged in a head to tail fashion.

Subcellular Location:
Cytoplasm. Melanosome. Identified by mass spectrometry in melanosome fractions from stage I to stage IV.

Tissue Specificity:
Ubiquitous. Prominent expression in brain, lung, and liver.

Similarity:
Contains 1 acyl carrier domain.

SWISS:
P49327

Gene ID:
2194

Database links:

Entrez Gene: 2194 Human

Entrez Gene: 14104 Mouse

Entrez Gene: 50671 Rat

Entrez Gene: 281152 Cow

Omim: 600212 Human

SwissProt: P12276 Chicken

SwissProt: Q71SP7 Cow

SwissProt: P49327 Human

SwissProt: P19096 Mouse

SwissProt: P12785 Rat

Unigene: 8951 Chicken

Unigene: 30099 Cow

Unigene: 83190 Human

Unigene: 236443 Mouse

Unigene: 9486 Rat



產品圖片
25 ug total protein per lane of various lysates (see on figure) probed with FASN monoclonal antibody, unconjugated (bsm-51155M) at 1:4000 dilution and 4°C overnight incubation. Followed by conjugated secondary antibody incubation at r.t. for 60 min.
Paraformaldehyde-fixed, paraffin embedded (human breast carcinoma); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Incubation with (FASN) Monoclonal Antibody, Unconjugated (bsm-51155M) at 1:200 overnight at 4°C, followed by operating according to SP Kit(Mouse)(sp-0024) instructionsand DAB staining.
Paraformaldehyde-fixed, paraffin embedded (human breast); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Incubation with (FASN) Monoclonal Antibody, Unconjugated (bsm-51155M) at 1:200 overnight at 4°C, followed by operating according to SP Kit(Mouse)(sp-0024) instructionsand DAB staining.
Paraformaldehyde-fixed, paraffin embedded (human liver carcinoma); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Incubation with (FASN) Monoclonal Antibody, Unconjugated (bsm-51155M) at 1:200 overnight at 4°C, followed by operating according to SP Kit(Mouse)(sp-0024) instructionsand DAB staining.
Paraformaldehyde-fixed, paraffin embedded (human lung carcinoma); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Incubation with (FASN) Monoclonal Antibody, Unconjugated (bsm-51155M) at 1:200 overnight at 4°C, followed by operating according to SP Kit(Mouse)(sp-0024) instructionsand DAB staining.
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