| 產(chǎn)品編號(hào) | bs-20711R |
| 英文名稱 | Rabbit Anti-B7H4 antibody |
| 中文名稱 | B7-H4抗體 |
| 別 名 | B7-H4; B7h4; B7S1; B7x; BC032925; Immune costimulatory protein B7H4; MGC41287; PRO1291; T cell costimulatory molecule B7x; V set domain-containing T cell activation inhibitor 1; VCTN1; VTCN1_HUMAN. |
| 研究領(lǐng)域 | 腫瘤 免疫學(xué) 轉(zhuǎn)錄調(diào)節(jié)因子 |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | Human,Mouse,Rat (predicted: Rabbit,Pig,Sheep,Cow) |
| 產(chǎn)品應(yīng)用 | WB=1:500-2000
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理論分子量 | 28kDa |
| 細(xì)胞定位 | 細(xì)胞膜 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human B7H4: 151-250/282 <Extracellular> |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 緩 沖 液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事項(xiàng) | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 產(chǎn)品介紹 |
B7-H4 protein is expressed on the surface of a variety of immune cells and functions as a negative regulator of T cell responses. While B7-H4 mRNA is widely distributed in mouse and human peripheral tissues, cell surface expression of B7-H4 protein is limited and shows an inducible pattern on hematopoietic cells. Putative receptor of B7-H4 can be upregulated on activated T cells. By arresting cell cycle, B7-H4 ligation of T cells has a profound inhibitory effect on the growth, cytokine secretion, and development of cytotoxicity. Administration of B7-H4Ig into mice impairs antigen-specific T cell responses whereas blockade of endogenous B7-H4 by specific monoclonal antibody promotes T cell responses. B7-H4 thus may participate in negative regulation of cell-mediated immunity in peripheral tissues. Function: Negatively regulates T-cell-mediated immune response by inhibiting T-cell activation, proliferation, cytokine production and development of cytotoxicity. When expressed on the cell surface of tumor macrophages, plays an important role, together with regulatory T-cells (Treg), in the suppression of tumor-associated antigen-specific T-cell immunity. Involved in promoting epithelial cell transformation. Subcellular Location: cell membrane; Single-pass type I membrane protein (Potential). Note=Expressed at the cell surface. A soluble form has also been detected. Tissue Specificity: Overexpressed in breast, ovarian, endometrial, renal cell (RCC) and non-small-cell lung cancers (NSCLC). Expressed on activated T- and B-cells, monocytes and dendritic cells, but not expressed in most normal tissues (at protein level). Widely expressed, including in kidney, liver, lung, ovary, placenta, spleen and testis. Post-translational modifications: N-glycosylated. Similarity: Belongs to the immunoglobulin superfamily. BTN/MOG family. Contains 2 Ig-like V-type (immunoglobulin-like) domains. SWISS: Q7Z7D3 Gene ID: 79679 Database links: Entrez Gene: 79679 Human Entrez Gene: 242122 Mouse Omim: 608162 Human SwissProt: Q7Z7D3 Human SwissProt: Q7TSP5 Mouse Unigene: 546434 Human Unigene: 137467 Mouse Unigene: 160956 Rat B7-H4(B7 Homolog 4)是B7家族中的新成員,它能通過抑制T細(xì)胞的增殖、細(xì)胞因子的產(chǎn)生和細(xì)胞周期的進(jìn)程來負(fù)性調(diào)控T細(xì)胞的免疫應(yīng)答,其大量表達(dá)B7-H4還可以促進(jìn)上皮細(xì)胞的惡性轉(zhuǎn)化,保護(hù)表皮細(xì)胞免于失巢凋亡,在腫瘤的發(fā)生,進(jìn)展和轉(zhuǎn)歸中發(fā)揮重要作用. 目前對(duì)B7-H4信號(hào)通路的進(jìn)一步的研究必將為自身免疫性疾病、病毒感染性疾病和器官移植后排斥反應(yīng)中T細(xì)胞介導(dǎo)的免疫應(yīng)答調(diào)控提供了新的途徑,同時(shí)也為腫瘤的診斷、治療提供嶄新的前景。 |
