| 產(chǎn)品編號(hào) | bs-20412R |
| 英文名稱 | Rabbit Anti-TGF beta 2 antibody |
| 中文名稱 | 轉(zhuǎn)化生長(zhǎng)因子β2（TGFβ2）抗體 |
| 別 名 | Transforming growth factor beta-2 proprotein; TGFB2; TGF B2; BSC 1 cell growth inhibitor; BSC-1 cell growth inhibitor; BSC1 cell growth inhibitor; Cetermin; G TSF; G-TSF; Glioblastoma derived T cell suppressor ; Glioblastoma derived T cell suppressor factor; Glioblastoma-derived T-cell suppressor factor; GTSF; MGC116892; Polyergin; TGF beta2; TGF-beta-2; TGF-beta2; TGFB 2; TGFB2_HUMAN; Transforming growth factor beta 2; Transforming growth factor beta-2. |
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Specific References (4) | bs-20412R has been referenced in 4 publications.
[IF=8.702] Xiao, Jiangwei. et al. IRE1α arm of unfolded protein response in muscle-specific TGF-β signaling-mediated regulation of muscle cell immunological properties. CELL MOL BIOL LETT. 2023 Dec;28(1):1-24 WB ; Mouse.
[IF=6.543] Zhong Li. et al. The TBX1/miR-193a-3p/TGF-β2 Axis Mediates CHD by Promoting Ferroptosis. Oxid Med Cell Longev. 2022;2022:5130546 WB ; Human.
[IF=5.191] Chao Ye. et al. Naringin in the repair of knee cartilage injury via the TGF-β/ALK5/Smad2/3 signal transduction pathway combined with an acellular dermal matrix. J Orthop Transl. 2021 Aug;: IHC ; Rabbit.
[IF=2.379] Weiwei Liu. et al. CircHIPK3 regulates cardiac fibroblast proliferation, migration and phenotypic switching through the miR-152-3p/TGF-β2 axis under hypoxia. 2020 Aug 25 WB ; Mouse.
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| 研究領(lǐng)域 | 腫瘤 細(xì)胞生物 信號(hào)轉(zhuǎn)導(dǎo) 干細(xì)胞 生長(zhǎng)因子和激素 轉(zhuǎn)錄調(diào)節(jié)因子 |
| 抗體來(lái)源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | Human,Mouse,Rat |
| 產(chǎn)品應(yīng)用 | WB=1:500-2000,ICC/IF=1:100-500,ELISA=1:5000-10000
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理論分子量 | 50kDa |
| 細(xì)胞定位 | 分泌型蛋白 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human TGF beta 2: 351-414/414 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 緩 沖 液 | Preservative: 0.02% Proclin300, Constituents: 1% BSA, 0.01M PBS, pH7.4. |
| 保存條件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事項(xiàng) | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 產(chǎn)品介紹 |
Transforming growth factor beta s (TGF beta s) were originally discovered due to their ability to promote anchorage-independent growth of rat NRK fibroblasts in the presence of TGF Alpha. It is now realized that TGF beta s mediate many cell-cell interactions that occur during embryonic development. Three TGF beta s have been identified in mammals. TGF beta 1, TGF beta 2 and TGF beta 3 are each synthesized as precursor proteins that are very similar in that each is cleaved to yield a 112 amino acid polypeptide that remains associated with the latent portion of the molecules. Biologically active TGF beta requires dimerization of the monomers (usually homodimers) and release of the latent peptide portion. Overall, the mature region of the TGF beta 3 protein has approximately 80% identity to the mature region of both TGF beta 1 and TGF beta 2. However, the NH2 terminals or precursor regions of their molecules share only 27% sequence identity. Function: TGF-beta 2 has suppressive effects on interleukin-2 dependent T-cell growth. Subunit: Homodimer; disulfide-linked. Heterodimers with TGFB1 and with TGFB3 have been found in bone. Interacts with the serine proteases, HTRA1 and HTRA3. Interacts with ASPN. Subcellular Location: Secreted. Similarity: Belongs to the TGF-beta family. SWISS: P61812 Gene ID: 7042 Database links: Entrez Gene: 7042 Human Entrez Gene: 21808 Mouse Omim: 190220 Human SwissProt: P61812 Human SwissProt: P27090 Mouse Unigene: 133379 Human Unigene: 18213 Mouse |
| 產(chǎn)品圖片 |
Sample: MDA-MB-231 (human)cell Lysate at 40 ug
Primary: Anti- TGF beta2 (bs-20412R)at 1/300 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 50 kD
Observed band size: 48 kD
Sample:
Placenta (Mouse)Lysate at 40 ug
Bladder (Mouse)Lysate at 40 ug
Primary: Anti-TGF beta 2(bs-20412R)at 1/300 dilution
Secondary: IRDye800CW Goat Anti-RabbitIgG at 1/20000 dilution
Predicted band size: 50kD
Observed band size: 50kD
Sample:
Lane 1: Mouse Heart tissue lysates
Lane 2: Rat Heart tissue lysates
Primary: Anti-TGF beta 2 (bs-20412R) at 1/1000 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 50 kDa
Observed band size: 50 kDa
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