| 產(chǎn)品編號 | bs-12584R |
| 英文名稱 | Rabbit Anti-PDE6A antibody |
| 中文名稱 | 磷酸二酯酶6α抗體 |
| 別 名 | PDE6 alpha; 5''-cyclic phosphodiesterase subunit alpha; CGPR A; GMP PDE alpha; GMP-PDE alpha; PDE 6 alpha; PDE 6A; PDE V B1; PDE V-B1; PDE6A; PDE6A_HUMAN; PDEA; Phosphodiesterase 6 alpha; Phosphodiesterase 6A alpha subunit; Phosphodiesterase 6A cGMP specific rod alpha; Retinal Rod Photoreceptor cGMP Phosphodiesterase alpha; Rod cGMP specific 3' 5' cyclic phosphodiesterase alpha subunit; Rod cGMP-specific 3''. |
| 研究領(lǐng)域 | 細(xì)胞生物 神經(jīng)生物學(xué) 信號轉(zhuǎn)導(dǎo) 細(xì)胞膜蛋白 |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | (predicted: Human,Mouse,Rat) |
| 產(chǎn)品應(yīng)用 | ELISA=1:5000-10000
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理論分子量 | 99kDa |
| 細(xì)胞定位 | 細(xì)胞膜 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human PDE6A: 101-200/860 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 緩 沖 液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事項 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 產(chǎn)品介紹 |
This gene encodes the cyclic-GMP (cGMP)-specific phosphodiesterase 6A alpha subunit, expressed in cells of the retinal rod outer segment. The phosphodiesterase 6 holoenzyme is a heterotrimer composed of an alpha, beta, and two gamma subunits. cGMP is an important regulator of rod cell membrane current, and its dynamic concentration is established by phosphodiesterase 6A cGMP hydrolysis and guanylate cyclase cGMP synthesis. The protein is a subunit of a key phototransduction enzyme and participates in processes of transmission and amplification of the visual signal. Mutations in this gene have been identified as one cause of autosomal recessive retinitis pigmentosa. [provided by RefSeq, Jul 2008] Function: This protein participates in processes of transmission and amplification of the visual signal. Subcellular Location: Cell membrane. DISEASE: Defects in PDE6A are the cause of retinitis pigmentosa type 43 (RP43) [MIM:613810]. RP43 is a retinal dystrophy belonging to the group of pigmentary retinopathies. Retinitis pigmentosa is characterized by retinal pigment deposits visible on fundus examination and primary loss of rod photoreceptor cells followed by secondary loss of cone photoreceptors. Patients typically have night vision blindness and loss of midperipheral visual field. As their condition progresses, they lose their far peripheral visual field and eventually central vision as well. Similarity: Belongs to the cyclic nucleotide phosphodiesterase family. Contains 2 GAF domains. SWISS: P16499 Gene ID: 5145 Database links: Entrez Gene: 5145 Human Entrez Gene: 225600 Mouse Omim: 180071 Human SwissProt: P16499 Human SwissProt: P27664 Mouse Unigene: 4147 Cow Unigene: 151710 Human Unigene: 567314 Human Unigene: 1370 Mouse Unigene: 391106 Mouse |
