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Rabbit Anti-PPP1R1C  antibody (bs-19991R)  
~~~促銷代碼KT202411~~~
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產品編號 bs-19991R
英文名稱 Rabbit Anti-PPP1R1C  antibody
中文名稱 蛋白磷酸酶1調節亞基1c抗體
別    名 Inhibitor 5 of protein phosphatase 1; IPP5; PP1 inhibitor protein 5; Ppp1r1c; PPR1C_HUMAN; Protein phosphatase 1 regulatory subunit 1A; Protein phosphatase 1 regulatory subunit 1C; protein phosphatase 1, regulatory (inhibitor) subunit 1C.  
研究領域 細胞生物  神經生物學  信號轉導  激酶和磷酸酶  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 (predicted: Human,Mouse,Rat,Rabbit,Dog)
產品應用 IHC-P=1:100-500,IHC-F=1:100-500,ICC/IF=1:100-500,IF=1:100-500,ELISA=1:5000-10000
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理論分子量 12kDa
細胞定位 細胞漿 
性    狀 Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human PPP1R1C: 1-100/567 
亞    型 IgG
純化方法 affinity purified by Protein A
緩 沖 液 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存條件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事項 This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
產品介紹 This gene encodes a cAMP-regulated phosphoprotein. The encoded protein is enriched in the caudate nucleus and cerebellar cortex. A similar protein in mouse may be involved in regulating the effects of dopamine in the basal ganglia. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jun 2012]

Function:
Isoform 2 may act as a competitive inhibitor of calmodulin-dependent enzymes such as calcineurin in neurons.

Subcellular Location:
Cytoplasm.

Tissue Specificity:
Isoform 2 is expressed in brain. Isoform 1 is present in immature thymocytes (at protein level).

Post-translational modifications:
Phosphorylation at Ser-56 favors interaction with CALM1.
Isoform 1 is methylated by CARM1 in immature thymocytes.

Similarity:
Contains 1 R3H domain.

SWISS:
Q8WVI7

Gene ID:
151242

Database links:

Entrez Gene: 10777 Human

Entrez Gene: 74100 Mouse

Entrez Gene: 363153 Rat

Omim: 605488 Human

SwissProt: Q9UBL0 Human

SwissProt: Q9DCB4 Mouse

Unigene: 475902 Human

Unigene: 713605 Human

Unigene: 297444 Mouse



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