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Rabbit Anti-SIPA1L1  antibody (bs-17497R)  
~~~促銷代碼KT202411~~~
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產品編號 bs-17497R
英文名稱 Rabbit Anti-SIPA1L1  antibody
中文名稱 信號誘導增殖相關蛋白1樣蛋白1抗體
別    名 DKFZp686G1344; E6 targeted protein 1; E6TP1; H_DJ1140G11.1; High risk human papilloma viruses E6 oncoproteins targeted protein 1; KIAA0440; Signal induced proliferation associated 1 like 1; Signal induced proliferation associated 1 like protein 1; SIPA1 like protein 1; WUGSC:H_DJ1140G11.1.  
研究領域 腫瘤  細胞生物  發育生物學  信號轉導  干細胞  細菌及病毒  G蛋白信號  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 Mouse,Rat (predicted: Human,Pig,Sheep,Cow,Chicken,Dog,Horse)
產品應用 IHC-P=1:100-500,IHC-F=1:100-500,ICC/IF=1:100-500,IF=1:100-500,ELISA=1:5000-10000
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理論分子量 200kDa
細胞定位 細胞膜 
性    狀 Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human SIPA1L1: 1451-1550/1804 
亞    型 IgG
純化方法 affinity purified by Protein A
緩 沖 液 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存條件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事項 This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
產品介紹 SIPA1L1 (Signal-induced proliferation associated-like protein 1) is a member of the SIPA1 family of RapGAPs. SIPA1L1 was initially identified as a binding partner and degradation target of the E6 oncoprotein of high-risk papillomaviruses. Recently, it was discovered that Casein kinase I epsilon (CKIe), a Wnt-regulated kinase that regulates Wnt/b-catenin signaling, also can bind to the carboxy-terminus of SIPA1L1. CKIe phosphorylates SIPA1L1, thereby reducing its stability and alleviating its inhibition of Rap1, a protein required for Wnt8/CKIe-mediated gastrulation during embryogenesis, suggesting SIPA1L1 plays important roles in embryo development as well as control of cell proliferation.

Subcellular Location:
Intracellular

SWISS:
O43166

Gene ID:
26037

Database links:

Entrez Gene: 26037 Human

Entrez Gene: 217692 Mouse

Entrez Gene: 246212 Rat

SwissProt: O43166 Human

SwissProt: Q8C0T5 Mouse

SwissProt: O35412 Rat

Unigene: 654657 Human

Unigene: 261333 Mouse

Unigene: 10835 Rat



產品圖片
Paraformaldehyde-fixed, paraffin embedded (mouse brain tissue); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (SIPA1L1) Polyclonal Antibody, Unconjugated (bs-17497R) at 1:400 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining.
Paraformaldehyde-fixed, paraffin embedded (rat brain tissue); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (SIPA1L1) Polyclonal Antibody, Unconjugated (bs-17497R) at 1:400 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining.
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