| 產品編號 | bs-16622R |
| 英文名稱 | Rabbit Anti-SPPL2C antibody |
| 中文名稱 | 膜內蛋白酶5抗體 |
| 別 名 | IMP-5; IMP5; SPP2C_HUMAN; Intramembrane protease 5; Signal peptide peptidase-like 2C; SPP-like 2C; |
| 研究領域 | 細胞生物 泛素 細胞膜蛋白 |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應 | (predicted: Human,Mouse,Rat) |
| 產品應用 | IHC-P=1:100-500,IHC-F=1:100-500,ICC/IF=1:100-500,IF=1:100-500,ELISA=1:5000-10000
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理論分子量 | 72kDa |
| 細胞定位 | 細胞膜 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human SPPL2C: 361-460/684 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 緩 沖 液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事項 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 產品介紹 |
Intramembrane proteolysis is now widely recognized as an important physiological pathway required for reverse signaling and membrane protein degradation. Aspartyl intramembrane cleaving proteases of the GXGD-type play an important regulatory role in health and disease. Signal peptide peptidase (SPP) and SPP-like (SPPL) peptidases, such as SPPL2a, SPPL2b, IMP5, and SPPL3, belong to the family of GXGD aspartic proteases. The putative catalytic domains of SPP and SPPLs are embedded in membranes in an orientation predisposed to cleave type II oriented transmembrane proteins. IMP5 (intramembrane protease 5), also known as SPPL2c (signal peptide peptidase-like 2C), is a 690 amino acid multi-pass membrane protein that may act as an intramembrane protease. IMP5 also belongs to the peptidase A22B family and two isoforms are produced by alternative splicing events. Function: May act as intramembrane protease. Subcellular Location: Membrane. Similarity: Belongs to the peptidase A22B family. SWISS: Q8IUH8 Gene ID: 162540 Database links: Entrez Gene: 162540 Human Omim: 608284 Human SwissProt: Q8IUH8 Human Unigene: 144491 Human |
| 1、抗體溶解方法 | |
| 2、抗體修復方式 | |
| 3、常用試劑的配制 | |
| 4、免疫組化操作步驟 | |
| 5、免疫組化問題解答 | |
| 6、Western Blotting 操作步驟 | |
| 7、Western Blotting 問題解答 | |
| 8、關于肽鏈的設計 | |
| 9、多肽的溶解與保存 | |
| 10、酶標抗體效價測定程序 | |
