| 產(chǎn)品編號 | bs-13760R |
| 英文名稱 | Rabbit Anti-DCL-1 antibody |
| 中文名稱 | C型凝集素受體CLEC13A抗體 |
| 別 名 | CD302; CLEC13A; DCL1; C-type lectin domain family 13 member A; C-type lectin BIMLEC; CD302_HUMAN. |
| 研究領(lǐng)域 | 腫瘤 細(xì)胞生物 細(xì)胞粘附分子 細(xì)胞表面分子 |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | (predicted: Human,Mouse,Rat,Rabbit,Dog,Horse) |
| 產(chǎn)品應(yīng)用 | IHC-P=1:100-500,IHC-F=1:100-500,ICC/IF=1:100-500,IF=1:100-500,ELISA=1:5000-10000
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理論分子量 | 26kDa |
| 細(xì)胞定位 | 細(xì)胞膜 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human DCL-1: 51-150/232 <Extracellular> |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 緩 沖 液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事項 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 產(chǎn)品介紹 |
DCL-1 is a 232 amino acid single-pass type I membrane protein involved in endocytosis, phagocytosis and cell adhesion and migration. A C-type lectin receptor, DCL-1 is widely expressed with highest levels found in peripheral blood, myeloid and B lymphoid cell lines, liver, ovary and lung. DCL-1 undergoes alternative splicing to produce three isoforms designated DCL-1 isoform 1, isoform 2 (also known as fusion protein variant V34-2) and isoform 3 (also designated fusion protein variant V33-2). DCL-1 isoforms 2 and 3 are produced in malignant lympoma cells, known as Hodgkin and Reed-Sternberg (HRS) cells. DCL-1 contains one C-type lectin domain and is encoded by a gene that maps to human chromosome 2q24.2. A number of genetic diseases are linked to genes on chromosome 2 including Harlequin icthyosis, sitosterolemia and Alstr鰉 syndrome. Function: Expressed in myeloid and B lymphoid cell lines. Isoform 2 and isoform 3 are expressed in malignant Hodgkin lymphoma cells called Hodgkin and Reed-Sternberg (HRS) cells. Subcellular Location: Membrane. Similarity: Contains 1 C-type lectin domain. SWISS: Q8IX05 Gene ID: 9936 Database links: Entrez Gene: 9936 Human Entrez Gene: 66205 Mouse Omim: 612246 Human SwissProt: Q8IX05 Human SwissProt: Q9DCG2 Mouse Unigene: 130014 Human Unigene: 674903 Human Unigene: 227281 Mouse Unigene: 98436 Rat |
