| 產(chǎn)品編號 | bs-13259R |
| 英文名稱 | Rabbit Anti-GABA Transporter 2 antibody |
| 中文名稱 | γ氨基丁酸運載蛋白2抗體 |
| 別 名 | GABA transport protein; GAT 2; GAT-2; GAT2; Solute carrier family 6 (Neurotransmitter transporter, GABA), member 13; S6A13_HUMAN. |
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Specific References (1) | bs-13259R has been referenced in 1 publications.
[IF=2.27] Tai, Tran Tien, et al. "Neurotransmitter transporter family including SLC6A6 and SLC6A13 contributes to the 5‐aminolevulinic acid (ALA)‐induced accumulation of protoporphyrin IX and photo‐damage, through uptake of ALA by cancerous cells." Photochemistry and Photobiology (2014). IHC-P ; Human.
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| 研究領(lǐng)域 | 細胞生物 神經(jīng)生物學(xué) 細胞膜受體 轉(zhuǎn)運蛋白 |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | Human (predicted: Mouse,Rat,Rabbit,Pig,Sheep,Cow,Chicken,Dog,Horse) |
| 產(chǎn)品應(yīng)用 | ELISA=1:5000-10000
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理論分子量 | 68kDa |
| 細胞定位 | 細胞膜 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human GABA Transporter 2/GAT-2: 131-230/602 <Extracellular> |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 緩 沖 液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事項 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 產(chǎn)品介紹 |
GABA is a major inhibitory neurotransmitter and the GABAergic transmission is terminated by the rapid Na+/Cl-dependent uptake of through GABA transporters. There are multiple subtypes of GABA transporters (GAT1, GAT2, GAT3; and betaine GABA transporter (BGT-1). There is ~50% homology between each subtypes. GAT1 and GAT3 have been detected in various parts of the brain while GAT2 is found in many tissues. It appears that GAT1 and GAT3 are involved in distinct GABAergic transmission while GAT2 may be important in non-neural functions. GAT2 is a gamma-amino butyric acid (GABA) transporter. It is a 602 amino acid (85kDa) transmembrane protein. Function: Terminates the action of GABA by its high affinity sodium-dependent reuptake into presynaptic terminals. Subcellular Location: Membrane; Multi-pass membrane protein. Tissue Specificity: Expressed in brain, kidney, lung, liver and testis. Similarity: Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A13 subfamily. SWISS: Q8TCC2 Gene ID: 6540 Database links: Entrez Gene: 6540 Human Entrez Gene: 14412 Mouse SwissProt: Q8TCC2 Human SwissProt: Q9NSD5 Human SwissProt: P31649 Mouse |
