| 產品編號 | bs-12180R |
| 英文名稱 | Rabbit Anti-phospho-KIR5.1 (Ser416) antibody |
| 中文名稱 | 磷酸化細胞內流鉀通道蛋白Kir5.1抗體 |
| 別 名 | KIR5.1 (phospho Ser416); p-KIR5.1 (phospho S416); 6430410F18Rik; AI132396; BIR9; Inward rectifier K channel Kir5.1; Inward rectifier K(+) channel Kir5.1; Inward rectifier potassium channel 16; IRK16; IRKG; KCNJ16; MGC33717; Potassium channel inwardly rectifying subfamily J member 16; Potassium inwardly rectifying channel subfamily J member 16; RP23-218O16.1; IRK16_HUMAN. |
| 產品類型 | 磷酸化抗體 |
| 研究領域 | 腫瘤 細胞生物 神經生物學 信號轉導 通道蛋白 細胞膜受體 新陳代謝 |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應 | (predicted: Human,Mouse,Rat,Rabbit,Pig,Cow,Dog,Horse) |
| 產品應用 | IHC-P=1:100-500,IHC-F=1:100-500,ICC/IF=1:100-500,IF=1:100-500,ELISA=1:5000-10000
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理論分子量 | 48kDa |
| 細胞定位 | 細胞膜 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthesised phosphopeptide derived from human KIR5.1 around the phosphorylation site of Ser416: VE(p-S)QM |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 緩 沖 液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事項 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 產品介紹 |
The KIR family of potassium channels possess a greater tendency to allow potassium to flow into the cell rather than out of it. Kir4.1, also known as Kir1.2, is highly expressed in brain including glial cells, astrocytes and cortical neurons. Kir4.1 is also expressed in myelin-synthesizing oligodendrocytes and is crucial to myelination in the developing nervous system. The gene encoding human Kir4.1 maps to chromosome 1. Kir4.2, also known as Kir1.3, is expressed in kidney, lung, heart, thymus and thyroid during development. The gene encoding human Kir4.2 maps to chromosome 21 in the Down syndrome chromosome region 1, and Kir4.2 may play a role in the pathogenesis of Down’s syndrome. Kir 5.1 forms functional channels only by coexpression with either Kir4.1 or Kir4.2 in the kidney and pancreas. The gene encoding human Kir5.1 maps to chromosome 17. Function: KIR5.1 is one of 20 members of the inwardly rectifying potassium (Kir) channel family. Due to its expression in kidney, pancreas and thyroid gland, it has been suggested that human KIR5.1 may be involved in the regulation of fluid and pH balance, thus making it a potential therapeutic target for hypertension, renal failure, or pancreatic disease. Subunit: Seems to form heterodimer with Kir4.1/KCNJ10 or Kir2.1/KCNJ2. Subcellular Location: Membrane; Multi pass membrane protein. Tissue Specificity: Highly expressed in kidney, pancreas and thyroid gland. Similarity: Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family. KCNJ16 subfamily. SWISS: Q9NPI9 Gene ID: 3773 Database links: Entrez Gene: 3773 Human Entrez Gene: 16517 Mouse Omim: 605722 Human SwissProt: Q9NPI9 Human SwissProt: Q9Z307 Mouse Unigene: 463985 Human Unigene: 1989 Rat |
| 1、抗體溶解方法 | |
| 2、抗體修復方式 | |
| 3、常用試劑的配制 | |
| 4、免疫組化操作步驟 | |
| 5、免疫組化問題解答 | |
| 6、Western Blotting 操作步驟 | |
| 7、Western Blotting 問題解答 | |
| 8、關于肽鏈的設計 | |
| 9、多肽的溶解與保存 | |
| 10、酶標抗體效價測定程序 | |
