| 產(chǎn)品編號 | bs-12133R |
| 英文名稱 | Rabbit Anti-SCN3A antibody |
| 中文名稱 | 電壓門控鈉通道SCN3α蛋白/Na+ CP type IIIα抗體 |
| 別 名 | NAC3; Sodium channel protein type 3 subunit alpha; Sodium channel protein type III subunit alpha; Sodium channel protein, brain III subunit alpha; Voltage gated sodium channel subtype III; Voltage gated sodium channel subunit alpha Nav1.3; SCN3A_HUMAN. |
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Specific References (1) | bs-12133R has been referenced in 1 publications.
[IF=3.612] Bo Pang. et al. MiR-214-3p plays a protective role in diabetic neuropathic rats by regulating Nav1.3 and TLR4. 2021 Jul 23 WB ; Rat.
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| 研究領(lǐng)域 | 神經(jīng)生物學(xué) 通道蛋白 細(xì)胞膜受體 |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | (predicted: Human,Mouse,Rat,Pig,Cow,Chicken) |
| 產(chǎn)品應(yīng)用 | IHC-P=1:100-500,IHC-F=1:100-500,ICC/IF=1:100-500,IF=1:100-500,ELISA=1:5000-10000
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理論分子量 | 226kDa |
| 細(xì)胞定位 | 細(xì)胞膜 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human SCN3A: 1401-1600/2000 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 緩 沖 液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事項(xiàng) | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 產(chǎn)品介紹 |
Voltage-gated sodium channels are transmembrane glycoprotein complexes composed of a large alpha subunit with 24 transmembrane domains and one or more regulatory beta subunits. They are responsible for the generation and propagation of action potentials in neurons and muscle. This gene encodes one member of the sodium channel alpha subunit gene family, and is found in a cluster of five alpha subunit genes on chromosome 2. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].
Function: Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. Subunit: The sodium channel consists of a large polypeptide and 2-3 smaller ones. This sequence represents a large polypeptide. Interacts with NEDD4L. Subcellular Location: Membrane; Multi-pass membrane protein. Post-translational modifications: May be ubiquitinated by NEDD4L; which would promote its endocytosis. Similarity: Belongs to the sodium channel (TC 1.A.1.10) family. Nav1.3/SCN3A subfamily. Contains 1 IQ domain. SWISS: Q9NY46 Gene ID: 6328 Database links: Entrez Gene: 6328 Human Entrez Gene: 20269 Mouse Omim: 182391 Human SwissProt: Q9NY46 Human Unigene: 435274 Human Unigene: 330256 Mouse Unigene: 87394 Rat |
