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Rabbit Anti-TP53I8  antibody (bs-6637R)  
~~~促銷代碼KT202411~~~
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產(chǎn)品編號 bs-6637R
英文名稱 Rabbit Anti-TP53I8  antibody
中文名稱 腫瘤蛋白p53誘導(dǎo)蛋白8抗體
別    名 Ei24; EI24_HUMAN; EPG4; Etoposide induced 2.4 mRNA; Etoposide-induced protein 2.4 homolog; p53-induced gene 8 protein; PIG8; TP53I8; Tumor protein p53 inducible protein 8.  
研究領(lǐng)域 腫瘤  細胞生物  腫瘤細胞生物標志物  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) (predicted: Human,Mouse,Rat,Pig,Cow,Dog,Horse)
產(chǎn)品應(yīng)用 IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500,ELISA=1:5000-10000
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理論分子量 39kDa
細胞定位 細胞核 細胞漿 細胞膜 
性    狀 Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human TP53I8/EI24: 251-340/340 
亞    型 IgG
純化方法 affinity purified by Protein A
緩 沖 液 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存條件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事項 This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
產(chǎn)品介紹 This gene has higher expression in p53-expressing cells than in control cells and is an immediate-early induction target of p53-mediated apoptosis. The protein encoded by this gene contains six putative transmembrane domains and may suppress cell growth by inducing apoptotic cell death through the caspase 9 and mitochondrial pathways. This gene is located on human chromosome 11q24, a region frequently altered in cancers. Alternative splicing results in two transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008].

Function:
Acts as a negative growth regulator via p53-mediated apoptosis pathway. Regulates formation of degradative autolysosomes during autophagy.

Subunit:
Interacts with BCL2.

Subcellular Location:
Nucleus membrane; Multi-pass membrane protein. Cytoplasm. Endoplasmic reticulum membrane; Multi-pass membrane protein.

DISEASE:
Note=EI24 is on a chromosomal region frequently deleted in solid tumors, and it is thought to play a role in breast and cervical cancer. Particularly, expression analysis of EI24 in cancerous tissues shows that EI24 loss is associated with tumor invasiveness.

Similarity:
Belongs to the EI24 family.

SWISS:
O14681

Gene ID:
9538

Database links:

Entrez Gene: 9538 Human

Entrez Gene: 13663 Mouse

Entrez Gene: 300514 Rat

Omim: 605170 Human

SwissProt: O14681 Human

SwissProt: Q61070 Mouse

SwissProt: Q4KM77 Rat

Unigene: 643514 Human



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