| 產品編號 | bs-2014R |
| 英文名稱 | Rabbit Anti-SCP2 antibody |
| 中文名稱 | 固醇攜帶蛋白2抗體 |
| 別 名 | DKFZp686C12188; DKFZp686D11188; NLTP; Nonspecific lipid transfer protein; NSL TP; OTTHUMP00000010488; Propanoyl CoA C acyltransferase; SCP 2; SCP chi; SCP X; SCP2; SCPchi; SCPX; Sterol carrier protein 2; Sterol carrier protein X; NLTP_HUMAN. |
| 研究領域 | 心血管 細胞生物 免疫學 染色質和核信號 細胞周期蛋白 合成與降解 細胞分化 細胞骨架 線粒體 |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應 | (predicted: Human,Mouse,Rat,Rabbit,Cow,Dog) |
| 產品應用 | IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500,ELISA=1:5000-10000
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理論分子量 | 59kDa |
| 細胞定位 | 細胞漿 線粒體 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human SCP2: 451-547/547 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 緩 沖 液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事項 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 產品介紹 |
This gene encodes two proteins: sterol carrier protein X(SCPx) and sterol carrier protein 2 (SCP2), as a result of transcription initiation from 2 independently regulated promoters. The transcript initiated from the proximal promoter encodes the longer SCPx protein, and the transcript initiated from the distal promoter encodes the shorter SCP2 protein, with the 2 proteins sharing a common C-terminus. Evidence suggests that the SCPx protein is a peroxisome-associated thiolase that is involved in the oxidation of branched chain fatty acids, while the SCP2 protein is thought to be an intracellular lipid transfer protein. This gene is highly expressed in organs involved in lipid metabolism, and may play a role in Zellweger syndrome, in which cells are deficient in peroxisomes and have impaired bile acid synthesis. Alternative splicing of this gene produces multiple transcript variants, some encoding different isoforms. [provided by RefSeq, Aug 2010] Function: Mediates in vitro the transfer of all common phospholipids, cholesterol and gangliosides between membranes. May play a role in regulating steroidogenesis. Subunit: Interacts with PEX5. Subcellular Location: Cytoplasm. Mitochondrion. Note=Cytoplasmic in the liver and also associated with mitochondria especially in steroidogenic tissues. Isoform SCPx: Peroxisome. Note=Interaction with PEX5 is essential for peroxisomal import. Isoform SCP2: Mitochondrion (Probable). Tissue Specificity: Liver, fibroblasts, and placenta. DISEASE: Leukoencephalopathy, with dystonia and motor neuropathy (LDMN) [MIM:613724]: A syndrome characterized by leukoencephalopathy, dystonic head tremor, spasmodic torticollis and reduced tendon reflexes in lower extremities. Additional features include hyposmia, pathologic saccadic eye movements, a slight hypoacusis, accumulation of branched-chain pristanic acid in plasma, and the presence of abnormal bile alcohol glucuronides in urine. Note=The disease is caused by mutations affecting the gene represented in this entry. Similarity: In the N-terminal section; belongs to the thiolase family. Contains 1 SCP2 domain. SWISS: P22307 Gene ID: 6342 Database links: Entrez Gene: 6342 Human Entrez Gene: 20280 Mouse Omim: 184755 Human SwissProt: P22307 Human SwissProt: P32020 Mouse Unigene: 476365 Human Unigene: 379011 Mouse Unigene: 31887 Rat 固醇攜帶蛋白2(SCP2)參與了膽固醇的合成、代謝和轉運過程.與膽囊固醇結石形成有關. |
| 1、抗體溶解方法 | |
| 2、抗體修復方式 | |
| 3、常用試劑的配制 | |
| 4、免疫組化操作步驟 | |
| 5、免疫組化問題解答 | |
| 6、Western Blotting 操作步驟 | |
| 7、Western Blotting 問題解答 | |
| 8、關于肽鏈的設計 | |
| 9、多肽的溶解與保存 | |
| 10、酶標抗體效價測定程序 | |
