| 產(chǎn)品編號 | bs-0922R |
| 英文名稱 | Rabbit Anti-Neurogenin3 antibody |
| 中文名稱 | 神經(jīng)元素3抗體 |
| 別 名 | NGN3; NGN-3; neurogenin 3; Neurog3; Neurogenin-3; ATH4B; Atoh5; Math4B; NEUROG3; ngn3; OTTHUMP00000019730; Protein atonal homolog 5; Class A basic helix-loop-helix protein 7; NGN3_HUMAN. 神經(jīng)營養(yǎng)素-3; |
 |
Specific References (2) | bs-0922R has been referenced in 2 publications.
[IF=2.08] Jian, Ruo-Lei, et al. "Generation of insulin-producing cells from C3H10T1/2 mesenchymal progenitor cells." Gene (2015). WB ; Mouse.
[IF=0] Wenhuan Chai. et al. Visualizing Cathepsin K-Cre Expression at the Single-Cell Level with GFP Reporters. JBMR Plus. 2022 Dec;:e10706 IF ; Mouse.
|
| 研究領(lǐng)域 | 細(xì)胞生物 神經(jīng)生物學(xué) 干細(xì)胞 轉(zhuǎn)錄調(diào)節(jié)因子 表觀遺傳學(xué) |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | Human,Mouse (predicted: Rat,Sheep,Cow,Dog) |
| 產(chǎn)品應(yīng)用 | WB=1:500-2000,ELISA=1:5000-10000
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理論分子量 | 23kDa |
| 細(xì)胞定位 | 細(xì)胞核 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human NGN3: 61-160/214 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 緩 沖 液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事項 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 產(chǎn)品介紹 |
Neurogenin-3 (NEUROG3) is expressed in endocrine progenitor cells and is required for endocrine cell development in the pancreas and intestine (Wang et al., 2006 [PubMed 16855267]). It belongs to a family of basic helix-loop-helix transcription factors involved in the determination of neural precursor cells in the neuroectoderm. Function: Involved in neurogenesis. Also required for the specification of a common precursor of the 4 pancreatic endocrine cell types. Subcellular Location: Nucleus. DISEASE: Defects in NEUROG3 are the cause of diarrhea type 4 (DIAR4) [MIM:610370]. DIAR4 is a characterized by severe, life-threatening watery diarrhea associated with generalized malabsorption and a paucity of enteroendocrine cells. Similarity: Contains 1 basic helix-loop-helix (bHLH) domain. SWISS: Q9Y4Z2 Gene ID: 50674 Database links: Entrez Gene: 50674 Human Entrez Gene: 11925 Mouse Omim: 604882 Human SwissProt: Q9Y4Z2 Human SwissProt: P70661 Mouse Unigene: 532682 Human Unigene: 57236 Mouse 神經(jīng)生物學(xué)相關(guān)蛋白（Neurobiology） Ngn3屬于bHLH家族蛋白，是胰腺發(fā)育過程中短暫表達(dá)的蛋白，可能是胰腺內(nèi)分泌細(xì)胞系的定向因子，一般在成熟胰島中不存在。 Ngn3的表達(dá)會導(dǎo)致胰腺內(nèi)分泌細(xì)胞數(shù)的增加外分泌細(xì)胞數(shù)的減少。因而胰島β細(xì)胞并不是完全靠干細(xì)胞分化產(chǎn)生，主要是通過已分化胰島β細(xì)胞的分裂增殖。 但近年來，有學(xué)者認(rèn)為：Ngn3雖在胰腺發(fā)育中短暫表達(dá)，但是否存在使胰島干細(xì)胞或前體細(xì)胞自我更新的能力尚未明確定論。 |
| 產(chǎn)品圖片 |
Sample:Liver(Mouse) Lysate at 30 ug
Primary: Anti-Neurogenin3 (bs-0922R) at 1/300 dilution
Secondary: IRDye800CW Goat Anti-Mouse IgG at 1/20000 dilution
Predicted band size: 23 kD
Observed band size: 26 kD
|
