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Rabbit Anti-NF-H  antibody (bs-0708R)  
~~~促銷代碼KT202411~~~
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產品編號 bs-0708R
英文名稱 Rabbit Anti-NF-H  antibody
中文名稱 高分子量神經絲蛋白抗體
別    名 NFH_HUMAN; Neurofilament heavy polypeptide; NEFH; KIAA0845; NFH; NF H; NF200; NF-200; Neurofilament 200; 200 kDa neurofilament protein; Neurofilament triplet H protein; Neurofilament H; Neurofilament heavy polypeptide 200kD;  
Specific References  (12)     |     bs-0708R has been referenced in 12 publications.
[IF=5.682] Borgonetti, Vittoria. et al. Posttranscriptional Regulation of Gene Expression Participates in the Myelin Restoration in Mouse Models of Multiple Sclerosis: Antisense Modulation of HuR and HuD ELAV RNA Binding Protein. MOL NEUROBIOL. 2023 Jan;:1-17  WB,IF ;  Mouse.  
[IF=5.14] Zhao, Hua, et al. "Transplantation of Cerebral Dopamine Neurotrophic Factor Transducted BMSCs in Contusion Spinal Cord Injury of Rats: Promotion of Nerve Regeneration by Alleviating Neuroinflammation." Molecular neurobiology (2014): 1-13.  IHC-P ;  Rat.  
[IF=4.73] Erdal Ayhan I?ik. et al. Use of Erythropoietin and Fibrin Glue Mixture for Peripheral Nerve Repair. Plast Reconstr Surg. 2022 Feb;149(2):395-403  IHC ;  Rat.  
[IF=4.605] Laura E. Bruijn. et al. Extreme Diversity of the Human Vascular Mesenchymal Cell Landscape. J Am Heart Assoc. 2020;9:e017094  IHC ;  Human.  
[IF=4.051] Y?lmaz, Mahmut Muhsin. et al. Biological nerve conduit model with de-epithelialized human amniotic membrane and adipose-derived mesenchymal stem cell sheet for repair of peripheral nerve defects. CELL TISSUE RES. 2022 Dec;:1-18  IHC ;  Rat.  
[IF=3.998] Jian Kang. et al. Matrine treatment reduces retinal ganglion cell apoptosis in experimental optic neuritis. Sci Rep-Uk. 2021 May;11(1):1-12  WB ;  Rat.  
[IF=3.231] Chen S et al. PAM/GO/Gel/SA composite hydrogel conduit with bioactivity for repairing peripheral nerve injury. J Biomed Mater Res A. 2019 Jan 31.  IHF ;  Rat.  
[IF=2.997] Qiang Denget al. The role of protein kinase C alpha in tri‐ortho‐cresyl phosphate‐induced autophagy in Human neuroblastoma SK‐N‐SH cells. J Appl Toxicol . 2020 Nov;40(11):1480-1490.  WB ;  Human.  
[IF=2.795] Gang Wang. et al. MiR-195-5p inhibits proliferation and invasion of nerve cells in Hirschsprung disease by targeting GFRA4. 2021 Jan 30  IF ;  Human.  
[IF=2.677] Yu Chen. et al. Effect of necrostatin-1 on sciatic nerve crush injury in rat models. J ORTHOP SURG RES. 2023 Dec;18(1):1-9  IF,WB ;  Rat.  
[IF=2.41] Cheng, Lei, et al. "Lentiviral-mediated transfer of CDNF promotes nerve regeneration and functional recovery after sciatic nerve injury in adult rats."Biochemical and Biophysical Research Communications?(2013).  IHC-P ;  Rat.  
[IF=2.2] Wang, Nan, et al. "Myocardin-related transcription factor-A is key regulator in retinoic acid-induced neural-like differentiation of adult bone marrow-derived mesenchymal stem cells." Gene (2013).  WB ;  Rat.  
研究領域 細胞生物  神經生物學  信號轉導  細胞凋亡  轉錄調節因子  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 Human,Mouse,Rat
產品應用 IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理論分子量 118kDa
檢測分子量 200
細胞定位 細胞漿 
性    狀 Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human NF-H: 901-1000/1026 
亞    型 IgG
純化方法 affinity purified by Protein A
緩 沖 液 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存條件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事項 This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
產品介紹 Neurofilaments can be defined as the intermediate or 10nm filaments found in specifically in neuronal cells. When visualised using an electron microscope, neurofilaments appear as 10nm diameter fibres of indeterminate length that generally have fine wispy protrusions from their sides. They are particularly abundant in axons of large projection neurons. They probably function to provide structural support for neurons and their synapses and to support the large axon diameters required for rapid conduction of impulses down axons. Neurofilaments are composed of a mixture of subunits, which usually includes the three neurofilament triplet proteins neurofilament light (NFL), neurofilament medium (NFM) and neurofilament heavy (NFH). Neurofilaments may also include smaller amounts of peripherin, alpha internexin, nestin and in some cases vimentin. Antibodies to the various neurofilament subunits are very useful cell type markers since the proteins are among the most abundant of the nervous system, are expressed only in neurons, and are biochemically very stable. Some studies have shown that levels of neurofilament heavy and neurofilament light are elevated in patients with Alzheimer's disease, frontotemporal lobe dementia, and vascular dementia.

Function:
Neurofilaments usually contain three intermediate filament proteins: L, M, and H which are involved in the maintenance of neuronal caliber. NF-H has an important function in mature axons that is not subserved by the two smaller NF proteins.

Post-translational modifications:
There are a number of repeats of the tripeptide K-S-P, NFH is phosphorylated on a number of the serines in this motif. It is thought that phosphorylation of NFH results in the formation of interfilament cross bridges that are important in the maintenance of axonal caliber.
Phosphorylation seems to play a major role in the functioning of the larger neurofilament polypeptides (NF-M and NF-H), the levels of phosphorylation being altered developmentally and coincident with a change in the neurofilament function.
Phosphorylated in the Head and Rod regions by the PKC kinase PKN1, leading to inhibit polymerization.

DISEASE:
Defects in NEFH are a cause of susceptibility to amyotrophic lateral sclerosis (ALS) [MIM:105400]. ALS is a neurodegenerative disorder affecting upper and lower motor neurons, and resulting in fatal paralysis. Sensory abnormalities are absent. Death usually occurs within 2 to 5 years. The etiology is likely to be multifactorial, involving both genetic and environmental factors.

Similarity:
Belongs to the intermediate filament family.

SWISS:
P12036

Gene ID:
4744

Database links:

Entrez Gene: 4744 Human

Entrez Gene: 380684 Mouse

Entrez Gene: 24587 Rat

Omim: 162230 Human

SwissProt: P12036 Human

SwissProt: P19246 Mouse

SwissProt: P16884 Rat

Unigene: 198760 Human

Unigene: 298283 Mouse

Unigene: 108194 Rat



產品圖片
Paraformaldehyde-fixed, paraffin embedded (mouse cerebellum); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (NF-H) Polyclonal Antibody, Unconjugated (bs-0708R) at 1:200 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining.
Paraformaldehyde-fixed, paraffin embedded (rat cerebellum); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (NF-H) Polyclonal Antibody, Unconjugated (bs-0708R) at 1:200 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining.
Paraformaldehyde-fixed, paraffin embedded (rat brain); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (NF-H) Polyclonal Antibody, Unconjugated (bs-0708R) at 1:200 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining.
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