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Rabbit Anti-ACAN  antibody (bs-1223R)  
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產(chǎn)品編號(hào) bs-1223R
英文名稱 Rabbit Anti-ACAN  antibody
中文名稱 軟骨蛋白聚糖抗體
別    名 Aggrecan; Aggrecan core protein; Cartilage-specific proteoglycan core protein; CSPCP; Chondroitin sulfate proteoglycan core protein 1; Chondroitin sulfate proteoglycan 1; Aggrecan core protein 2; AGC1; CSPG1; MSK16; PGCA_HUMAN.  
Specific References  (24)     |     bs-1223R has been referenced in 24 publications.
[IF=7.6] Lei, Ming, et al. "Mesenchymal stem cell characteristics of dental pulp and periodontal ligament stem cells after< i> in vivo transplantation." Biomaterials (2014).  WB ;  Human.  
[IF=6.064] Donglei Liu. et al. Effect of viscoelastic properties of cellulose nanocrystal/collagen hydrogels on chondrocyte behaviors. FRONT BIOENG BIOTECH. 2022; 10: 959409  IHC ;  Rat.  
[IF=5.806] Félix Renaudin. et al. NADPH oxidase 4 deficiency attenuates experimental osteoarthritis in mice. RMD OPEN. 2023 Feb;9(1):e002856  IHC ;  Mouse.  
[IF=5.191] Wenhui Hu. et al. Farnesoid X receptor agonist attenuates subchondral bone osteoclast fusion and osteochondral pathologies of osteoarthritis via suppressing JNK1/2/NFATc1 pathway. Faseb J. 2022 Apr;36(4):e22243  IHC ;  Mouse.  
[IF=4.868] Liu Y et al. Aspirin-Mediated Attenuation of Intervertebral Disc Degeneration by Ameliorating Reactive Oxygen Species In Vivo and In Vitro. Oxid Med Cell Longev. 2019 Nov 6;2019:7189854.  ICF ;  Human.  
[IF=4.793] J. Song. et al. Proteomics analysis of hip articular cartilage identifies differentially expressed proteins associated with osteonecrosis of the femoral head. Osteoarthr Cartilage. 2021 Apr;:  IHC ;  Human.  
[IF=4.545] Kai Zhao. et al. Rhizoma drynariae total flavonoids inhibit the inflammatory response and matrix degeneration via MAPK pathway in a rat degenerative cervical intervertebral disc model. Biomed Pharmacother. 2021 Jun;138:111466  IF ;  Rat.  
[IF=4.46] Shi, Yang, et al. "Hypoxia combined with spheroid culture improves cartilage specific function in chondrocytes." Integrative Biology (2015).  Rat.  
[IF=4.352] Yi-Zhong Wanget al. Ryanodine receptor 1 mediated dexamethasone-induced chondrodysplasia in fetal rats. Biochim Biophys Acta Mol Cell Res . 2020 Oct;1867(10):118791.  IF, WB ;  rat.  
[IF=4.169] Cheng, Baixiang. et al. Distinctive Roles of Wnt Signaling in Chondrogenic Differentiation of BMSCs under Coupling of Pressure and Platelet-Rich Fibrin. Tissue Engineering and Regenerative Medicine. 2022 Apr;:1-15  WB ;  Rabbit.  
[IF=4.105] Wang Y et al. Ryanodine receptor 1 mediated dexamethasone-induced chondrodysplasia in fetal rats. Biochim Biophys Acta Mol Cell Res. 2020 Oct;1867(10):118791.  IHF ;  Rat.  
[IF=3.757] Changli Zhang. et al. PHLPP1 deficiency protects against age-related intervertebral disc degeneration. JOR SPINE. 2022 Sep;:e1224  IHC ;  Mouse.  
[IF=3.322] Tingting Xia. et al. Gardenoside ameliorates inflammation and inhibits ECM degradation in IL-1β-treated rat chondrocytes via suppressing NF-κB signaling pathways. BIOCHEM BIOPH RES CO. 2022 Dec;:  WB ;  Rat.  
[IF=2.784] Yang et al. miR-1307-3p suppresses the chondrogenic differentiation of human adipose-derived stem cells by targeting BMPR2. (2018) Int.J.Mol.Med. 42:3115-3124  WB ;  
[IF=2.751] Haoran Wang. et al. CKLF1 interference alleviates IL?1β?induced inflammation, apoptosis and degradation of the extracellular matrix in chondrocytes via CCR5. EXP THER MED. 2023 Jun;25(6):1-11  WB ;  Mouse.  
[IF=2.69] Hu, Ming‐Hsiao, et al. "Optimization of Puncture Injury to Rat Caudal Disc for Mimicking Early Degeneration of Intervertebral Disc." Journal of Orthopaedic Research (2017).  IHC-P ;  Rat.  
[IF=2.559] Zhou H et al.Leukemia inhibitory factor promotes extracellular matrix synthesis in degenerative nucleus pulposus cells via MAPK-ERK1/2 signaling pathway.(2018)Biochem Biophys Res Commun;507(1-4):253-2  IHC ;  Rabbit.  
[IF=2.535] Lei J et al. LncRNA SNHG1 Alleviates IL-1β-induced Osteoarthritis by Inhibiting miR-16-5p-mediated p38 MAPK and NF-κB Signaling Pathways. Biosci Rep. 2019 Aug 5. pii: BSR20191523.  WB ;  Human.  
[IF=2.447] Xuejun Dai. et al. Comparison of the differentiation abilities of bone marrow?derived mesenchymal stem cells and adipose?derived mesenchymal stem cells toward nucleus pulposus?like cells in three?dimensional culture. Exp Ther Med. 2021 Sep;22(3):1-9  WB ;  Rat.  
[IF=2.362] Zhao R et al. Interleukin-1 receptor antagonist protein (IL-1Ra) and miR-140 overexpression via pNNS-conjugated chitosan-mediated gene transfer enhances the repair of full-thickness cartilage defects in a rabbit model. Bone Joint Res. 2019 Apr 2;8(3):165-178.  WB ;  Human.  
[IF=2.348] Ren et al. Treatment of rabbit intervertebral disc degeneration with co-transfection by adeno-associated virus-mediated SOX9 and osteogenic protein-1 double genes in vivo. (2013) Int.J.Mol.Me. 32:1063-8  WB ;  Rabbit.  
[IF=2.15] Xu, Xilin, et al. "Danshen attenuates osteoarthritis-related cartilage degeneration through inhibition of NF-κB signaling pathway in vivo and in vitro." Biochemistry and Cell Biology (2017).  WB ;  Rabbit.  
[IF=1.8] Zhao, Yangfei, et al. "Effect of Choline on the Composition and Degradation Enzyme of Extracellular Matrix of Mice Chondrocytes Exposed to Fluoride."Biological Trace Element Research (2016): 1-7.  WB ;  Mouse.  
[IF=1.27] Liu, Yong, et al. "Lentivirus-mediated TGF-β3, CTGF and TIMP1 gene transduction as a gene therapy for intervertebral disc degeneration in an in vivo rabbit model." Experimental and Therapeutic Medicine.  WB ;  Rabbit.  
研究領(lǐng)域 免疫學(xué)  信號(hào)轉(zhuǎn)導(dǎo)  干細(xì)胞  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Mouse,Rat (predicted: Human,Rabbit,Pig,Cow,Chicken,Dog,Horse)
產(chǎn)品應(yīng)用 IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500,ELISA=1:5000-10000
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
細(xì)胞定位 分泌型蛋白 
性    狀 Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human ACAN: 101-220/2415 
亞    型 IgG
純化方法 affinity purified by Protein A
緩 沖 液 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存條件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事項(xiàng) This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
產(chǎn)品介紹 Aggrecan is a member of a family of large, aggregating proteoglycans (also including versican, brevican and neurocan) which is found in articular cartilage. Aggrecan is composed of three major domains: G1, G2, and G3. Between the G1 and G2 domains there is an interglobulin region (IGD). The IGD region is the major site of cleavage by specific proteases like metalloproteinases (MMPs) and aggrecanase. Aggrecan cleavage has been associated with a number of degenerative diseases including rheumatoid arthritis and osteoarthritis. There is evidence that this family of proteoglycans modulates cell adhesion, migration, and axonal outgrowth in the CNS.

Function:
Aggrecan has been detected in neural precursor cells (neurospheres; Kabos et al, 2004) During differentiation, neurospheres downregulate Chondroitin sulfate proteoglycans (CSPGs). Proliferating neural precursors synthesize lecticans, including aggrecan, which are downregulated with differentiation; suggesting a link between CSPGs and CNS precursor biology.

Subunit:
Interacts with FBLN1. Interacts with COMP.

Subcellular Location:
Secreted, extracellular space, extracellular matrix.

Tissue Specificity:
Restricted to cartilages.

Post-translational modifications:
Contains mostly chondroitin sulfate, but also keratan sulfate chains, N-linked and O-linked oligosaccharides. The release of aggrecan fragments from articular cartilage into the synovial fluid at all stages of human osteoarthritis is the result of cleavage by aggrecanase.

DISEASE:
Spondyloepiphyseal dysplasia type Kimberley (SEDK) [MIM:608361]: Spondyloepiphyseal dysplasias are a heterogeneous group of congenital chondrodysplasias that specifically affect epiphyses and vertebrae. The autosomal dominant SEDK is associated with premature degenerative arthropathy. Note=The disease is caused by mutations affecting the gene represented in this entry.
Spondyloepimetaphyseal dysplasia aggrecan type (SEMD-ACAN) [MIM:612813]: A bone disease characterized by severe short stature, macrocephaly, severe midface hypoplasia, short neck, barrel chest and brachydactyly. The radiological findings comprise long bones with generalized irregular epiphyses with widened metaphyses, especially at the knees, platyspondyly, and multiple cervical-vertebral clefts. Note=The disease is caused by mutations affecting the gene represented in this entry.
Osteochondritis dissecans short stature and early-onset osteoarthritis (OD) [MIM:165800]: A type of osteochondritis defined as a separation of cartilage and subchondral bone from the surrounding tissue, primarily affecting the knee, ankle and elbow joints. It is clinically characterized by multiple osteochondritic lesions in knees and/or hips and/or elbows, disproportionate short stature and early-onset osteoarthritis. Note=The disease is caused by mutations affecting the gene represented in this entry.

Similarity:
Belongs to the aggrecan/versican proteoglycan family.
Contains 1 C-type lectin domain.
Contains 1 EGF-like domain.
Contains 1 Ig-like V-type (immunoglobulin-like) domain.
Contains 4 Link domains.
Contains 1 Sushi (CCP/SCR) domain.

SWISS:
P16112

Gene ID:
176

Database links:

Entrez Gene: 403828 Dog

Entrez Gene: 176 Human

Entrez Gene: 11595 Mouse

Entrez Gene: 58968 Rat

Omim: 155760 Human

SwissProt: Q28343 Dog

SwissProt: P16112 Human

SwissProt: Q61282 Mouse

SwissProt: P07897 Rat

Unigene: 2159 Human

Unigene: 358571 Mouse

Unigene: 54503 Rat



Aggrecan是軟骨細(xì)胞外基質(zhì)的主要結(jié)構(gòu)成分之一。它與膠原蛋白網(wǎng)絡(luò)結(jié)合,維持軟骨彈性、緩沖壓力,承擔(dān)負(fù)荷,并有自我潤滑的性能。蛋白多糖的進(jìn)行性喪失是骨性關(guān)節(jié)病發(fā)病主要原因之一。
產(chǎn)品圖片
Paraformaldehyde-fixed, paraffin embedded Rat Embryo; Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15 min; Antibody incubation with ACAN Polyclonal Antibody, Unconjugated (bs-1223R) at 1:200 overnight at 4°C, followed by conjugation to the SP Kit (Rabbit, SP-0023) and DAB (C-0010) staining.
Paraformaldehyde-fixed, paraffin embedded Mouse Embryo; Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15 min; Antibody incubation with ACAN Polyclonal Antibody, Unconjugated (bs-1223R) at 1:200 overnight at 4°C, followed by conjugation to the SP Kit (Rabbit, SP-0023) and DAB (C-0010) staining.
Tissue/cell: mouse embryo tissue; 4% Paraformaldehyde-fixed and paraffin-embedded; Antigen retrieval: citrate buffer ( 0.01M, pH 6.0 ), Boiling bathing for 15min; Block endogenous peroxidase by 3% Hydrogen peroxide for 30min; Blocking buffer (normal goat serum,C-0005) at 37鈩? for 20 min; Incubation: Anti-Aggrecan1 Polyclonal Antibody, Unconjugated(bs-1223R) 1:200, overnight at 4擄C, followed by conjugation to the secondary antibody(SP-0023) and DAB(C-0010) staining
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