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Mouse Bax Ready-To-Use IHC Kit (IHC0281M)  
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產(chǎn)品編號(hào) IHC0281M
英文名稱 Mouse Bax Ready-To-Use IHC Kit
中文名稱 小鼠Bax即用型免疫組化試劑盒
別    名 BAX; BCL2L4; Bcl2-L-4; Bax-protein; BAX_HUMAN; BAXA  
保存條件 Please store components at the temperatures indicated on the individual tube labels. The kit is stable for 6 months from the date of receipt.
產(chǎn)品介紹 BAX is a members of the Bcl-2 Family and plays an important role in regulation of apoptosis. Whereas Bcl-2 is commonly regarded as an anti-apoptotic protein, BAX is considered to have a pro-apoptotic function. Regulation of apoptosis is supposed to involve both homo- and heterodimerization of different isoforms of BAX and Bcl-2. The Bax gene encodes different isoforms including Bax alpha (21 kDa) and Bax beta (24 kDa), whereas both isoforms contain the BH1, BH2 and BH3 domains, Bax beta has a unique carboxyl terminus and does not contain a hydrophobic transmembrane domain. Bcl-2 is also expressed in different Isoforms. Bcl-2 beta differs in the 3' UTR and coding region compared to variant alpha. Bcl-2 beta is shorter (22 kDa) and has a distinct C-terminus compared to Bcl-2 alpha (26 kDa). BAX is a member of the BCL-2 family of proteins, which function as regulators of apoptosis. Overexpression of BAX functions to promote cell death. BAX can form homodimers and is also able to heterodimerize with other BCL-2 related proteins.

產(chǎn)品圖片
Immunohistochemical analysis of paraffin embedded mouse spleen tissue slide using IHC0281M (Mouse Bax IHC Kit).
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